Open Access: The Effect of Neurorehabilitation on Multiple Sclerosis-Unlocking the Resting-State fMRI Data

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F21%3A43920598" target="_blank" >RIV/00023752:_____/21:43920598 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11120/21:43921671 RIV/68407700:21230/21:00350089

Výsledek na webu

<a href="https://www.frontiersin.org/articles/10.3389/fnins.2021.662784/full" target="_blank" >https://www.frontiersin.org/articles/10.3389/fnins.2021.662784/full</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3389/fnins.2021.662784" target="_blank" >10.3389/fnins.2021.662784</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Open Access: The Effect of Neurorehabilitation on Multiple Sclerosis-Unlocking the Resting-State fMRI Data

Popis výsledku v původním jazyce

Multiple Sclerosis (MS) is a severe neurological condition, the incidence of which is growing on a global scale, reporting over 2.2million cases worldwide in 2016 (Wallin et al., 2019). The symptoms associated with the disease vary and include gait and postural control changes, problems with vision, sensory symptoms, cognitive decline, depression, and others (Kister et al., 2013). Despite the seriousness of the condition, its’ relative rareness and heterogeneity obstructs the neuroimaging research that could identify brain-dependent patterns that play a role in the disease’s progression. It has been shown that acute relapse or chronic insult in people with MS may stimulate brain plasticity mechanisms—the intrinsic cascades of the brain to functionally and structurally reorganize itself in response to external stimuli. However, a gradual failure of these processes to manage the increasing structural and functional changes caused by demyelination may eventually lead to impairment (Pascual-Leone et al., 2005; Prosperini et al., 2015). It has been hypothesized that by supporting the brain plasticity mechanisms via regular cognitive and motoric exercise, the progression of the disease might be slowed down. The positive effect of neurorehabilitation on brain activity has already been studied to some degree. Rasova et al. reported an increased correlation of fMRI activity among hemispheres following 2 months of eclectic rehabilitative therapy. Furthermore, they also found a decrease of effective connectivity at supplementary motor areas (Rasova et al., 2005, 2015). This evidence was later supported by other groups finding a beneficial functional reorganization in the sensory-motor network after motor rehabilitation (Tavazzi et al., 2018; Fling et al., 2019; Prochazkova et al., 2020). Tomassini et al. (2012) studied brain plasticity for visuomotor practice in MS patients and found it preserved despite the extent of cerebral pathology. Another study observed a correlation between motor improvements and fMRI modifications in MS patients after watching and imitating videos of daily life (Rocca et al., 2019). However, as pointed out in a recent review, most of the research in this domain suffers from the use of small sets of volunteers, which usually does not exceed twenty (Prosperini and Di Filippo, 2019). This raises concerns about the interpretation and generalization of reported findings, and makes the idea of sharing data more desirable (and eventually inevitable) to gain credibility. Considering the above, we share resting-state fMRI activity profiles across 60 people with MS before and after 2 months of neuroproprioceptive “facilitation and inhibition” treatment.

Název v anglickém jazyce

Open Access: The Effect of Neurorehabilitation on Multiple Sclerosis-Unlocking the Resting-State fMRI Data

Popis výsledku anglicky

Multiple Sclerosis (MS) is a severe neurological condition, the incidence of which is growing on a global scale, reporting over 2.2million cases worldwide in 2016 (Wallin et al., 2019). The symptoms associated with the disease vary and include gait and postural control changes, problems with vision, sensory symptoms, cognitive decline, depression, and others (Kister et al., 2013). Despite the seriousness of the condition, its’ relative rareness and heterogeneity obstructs the neuroimaging research that could identify brain-dependent patterns that play a role in the disease’s progression. It has been shown that acute relapse or chronic insult in people with MS may stimulate brain plasticity mechanisms—the intrinsic cascades of the brain to functionally and structurally reorganize itself in response to external stimuli. However, a gradual failure of these processes to manage the increasing structural and functional changes caused by demyelination may eventually lead to impairment (Pascual-Leone et al., 2005; Prosperini et al., 2015). It has been hypothesized that by supporting the brain plasticity mechanisms via regular cognitive and motoric exercise, the progression of the disease might be slowed down. The positive effect of neurorehabilitation on brain activity has already been studied to some degree. Rasova et al. reported an increased correlation of fMRI activity among hemispheres following 2 months of eclectic rehabilitative therapy. Furthermore, they also found a decrease of effective connectivity at supplementary motor areas (Rasova et al., 2005, 2015). This evidence was later supported by other groups finding a beneficial functional reorganization in the sensory-motor network after motor rehabilitation (Tavazzi et al., 2018; Fling et al., 2019; Prochazkova et al., 2020). Tomassini et al. (2012) studied brain plasticity for visuomotor practice in MS patients and found it preserved despite the extent of cerebral pathology. Another study observed a correlation between motor improvements and fMRI modifications in MS patients after watching and imitating videos of daily life (Rocca et al., 2019). However, as pointed out in a recent review, most of the research in this domain suffers from the use of small sets of volunteers, which usually does not exceed twenty (Prosperini and Di Filippo, 2019). This raises concerns about the interpretation and generalization of reported findings, and makes the idea of sharing data more desirable (and eventually inevitable) to gain credibility. Considering the above, we share resting-state fMRI activity profiles across 60 people with MS before and after 2 months of neuroproprioceptive “facilitation and inhibition” treatment.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30103 - Neurosciences (including psychophysiology)

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Frontiers in Neuroscience

ISSN

1662-453X

e-ISSN

—

Svazek periodika

15

Číslo periodika v rámci svazku

"Article Number: 662784"

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

6

Strana od-do

1-6

Kód UT WoS článku

000659982200001

EID výsledku v databázi Scopus

2-s2.0-85107827082