Use of functional magnetic resonance imaging in the evaluation of neural plasticity in macular degeneration
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F25%3A10500958" target="_blank" >RIV/00216208:11150/25:10500958 - isvavai.cz</a>
Výsledek na webu
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=jqeUVX_8gq" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=jqeUVX_8gq</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3389/fnins.2025.1622244" target="_blank" >10.3389/fnins.2025.1622244</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Use of functional magnetic resonance imaging in the evaluation of neural plasticity in macular degeneration
Popis výsledku v původním jazyce
This review evaluates the use of functional Magnetic Resonance Imaging (fMRI) to investigate brain plasticity in Age-Related Macular Degeneration (AMD). An analysis of studies utilizing fMRI methods identified three primary research approaches: task-based fMRI (17 studies), resting-state fMRI (4 studies), and population receptive fields (pRF) with population connective fields modeling (pCF; 3 studies). The review outlines the principles behind each fMRI methodology and summarizes the key functional and morphological findings. Results consistently demonstrated significant structural and connectivity reorganization in the brains of individuals with AMD, suggesting that the brain undergoes adaptive responses to sensory loss. Voxel-based morphometric findings, measuring the gray matter volume loss in visual cortex, further confirm these structural changes, which appear to correlate with altered functional connectivity. These insights underscore the intricate relationship between sensory deficits and cognitive function in AMD and emphasize the potential for targeted therapeutic interventions. FMRI emerges as a vital tool in group studies for understanding the neural underpinnings of AMD and its broader cognitive implications.
Název v anglickém jazyce
Use of functional magnetic resonance imaging in the evaluation of neural plasticity in macular degeneration
Popis výsledku anglicky
This review evaluates the use of functional Magnetic Resonance Imaging (fMRI) to investigate brain plasticity in Age-Related Macular Degeneration (AMD). An analysis of studies utilizing fMRI methods identified three primary research approaches: task-based fMRI (17 studies), resting-state fMRI (4 studies), and population receptive fields (pRF) with population connective fields modeling (pCF; 3 studies). The review outlines the principles behind each fMRI methodology and summarizes the key functional and morphological findings. Results consistently demonstrated significant structural and connectivity reorganization in the brains of individuals with AMD, suggesting that the brain undergoes adaptive responses to sensory loss. Voxel-based morphometric findings, measuring the gray matter volume loss in visual cortex, further confirm these structural changes, which appear to correlate with altered functional connectivity. These insights underscore the intricate relationship between sensory deficits and cognitive function in AMD and emphasize the potential for targeted therapeutic interventions. FMRI emerges as a vital tool in group studies for understanding the neural underpinnings of AMD and its broader cognitive implications.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
30103 - Neurosciences (including psychophysiology)
Návaznosti výsledku
Projekt
Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Ostatní
Rok uplatnění
2025
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Frontiers in Neuroscience
ISSN
1662-453X
e-ISSN
1662-453X
Svazek periodika
19
Číslo periodika v rámci svazku
AUG
Stát vydavatele periodika
CH - Švýcarská konfederace
Počet stran výsledku
10
Strana od-do
1622244
Kód UT WoS článku
001568195200001
EID výsledku v databázi Scopus
2-s2.0-105015513848