Expression and Localization of AβPP in SH-SY5Y Cells Depends on Differentiation Stat

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F21%3A43920675" target="_blank" >RIV/00023752:_____/21:43920675 - isvavai.cz</a>

Výsledek na webu

<a href="https://content.iospress.com/articles/journal-of-alzheimers-disease/jad201409" target="_blank" >https://content.iospress.com/articles/journal-of-alzheimers-disease/jad201409</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3233/JAD-201409" target="_blank" >10.3233/JAD-201409</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Expression and Localization of AβPP in SH-SY5Y Cells Depends on Differentiation Stat

Popis výsledku v původním jazyce

Neuroblastoma cell line SH-SY5Y, due to its capacity to differentiate into neurons, easy handling, and low cost, is a common experimental model to study molecular events leading to Alzheimer&apos;s disease (AD). However, it is prevalently used in its undifferentiated state, which does not resemble neurons affected by the disease. Here, we show that the expression and localization of amyloid-β protein precursor (AβPP), one of the key molecules involved in AD pathogenesis, is dramatically altered in SH-SY5Y cells fully differentiated by combined treatment with retinoic acid and BDNF. We show that insufficient differentiation of SH-SY5Y cells results in AβPP mislocalization.

Název v anglickém jazyce

Expression and Localization of AβPP in SH-SY5Y Cells Depends on Differentiation Stat

Popis výsledku anglicky

Neuroblastoma cell line SH-SY5Y, due to its capacity to differentiate into neurons, easy handling, and low cost, is a common experimental model to study molecular events leading to Alzheimer&apos;s disease (AD). However, it is prevalently used in its undifferentiated state, which does not resemble neurons affected by the disease. Here, we show that the expression and localization of amyloid-β protein precursor (AβPP), one of the key molecules involved in AD pathogenesis, is dramatically altered in SH-SY5Y cells fully differentiated by combined treatment with retinoic acid and BDNF. We show that insufficient differentiation of SH-SY5Y cells results in AβPP mislocalization.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30210 - Clinical neurology

Projekt

<a href="/cs/project/LO1611" target="_blank" >LO1611: Udržitelnost pro Národní ústav duševního zdraví</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Alzheimer´s Disease

ISSN

1387-2877

e-ISSN

—

Svazek periodika

82

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

7

Strana od-do

485-491

Kód UT WoS článku

000677582000003

EID výsledku v databázi Scopus

2-s2.0-85111397319