Pretreatment Cancer-Related Cognitive Impairment in Hodgkin Lymphoma Patients

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F23%3A43921176" target="_blank" >RIV/00023752:_____/23:43921176 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:90249/23:00133240 RIV/00216208:11240/23:10470442 RIV/00216208:11110/23:10470442 RIV/00216208:11120/23:43926131 RIV/00064173:_____/23:43926131

Výsledek na webu

<a href="https://www.mdpi.com/1718-7729/30/10/652" target="_blank" >https://www.mdpi.com/1718-7729/30/10/652</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/curroncol30100652" target="_blank" >10.3390/curroncol30100652</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Pretreatment Cancer-Related Cognitive Impairment in Hodgkin Lymphoma Patients

Popis výsledku v původním jazyce

Background: Cancer-related cognitive impairment (CRCI) is one of the most serious side effects of cancer that negatively impacts the quality of life of cancer patients and survivors. There is evidence of CRCI in Hodgkin lymphoma patients (HL); however, there is a lack of studies examining the presence of cognitive deficits before starting any treatment in HL patients. Methods: Forty adult patients (N = 40) newly diagnosed with HL (with no previous cancer diagnoses) and 40 healthy controls (N = 40) matched for age, sex, education, and premorbid intellect completed the neuropsychological battery and subjective and objective measures of affective distress and quality of life. Results: The results showed impairment in three out of six cognitive domains: verbal memory and learning, speed of processing/psychomotor speed, and abstraction/executive functions in the HL patients before the initiation of any treatment. The speed of processing/psychomotor speed domain is negatively correlated with depression. Conclusion: Cognitive deterioration in verbal memory and learning and abstraction/executive functions domains in HL patients seems to occur before the initiation of treatment independently of anxiety, depression, or physical symptoms. This suggests that HL itself may cause cognitive deficits in these cognitive domains. However, the underlying causes of CRCI still remain unclear. © 2023 by the authors.

Název v anglickém jazyce

Pretreatment Cancer-Related Cognitive Impairment in Hodgkin Lymphoma Patients

Popis výsledku anglicky

Background: Cancer-related cognitive impairment (CRCI) is one of the most serious side effects of cancer that negatively impacts the quality of life of cancer patients and survivors. There is evidence of CRCI in Hodgkin lymphoma patients (HL); however, there is a lack of studies examining the presence of cognitive deficits before starting any treatment in HL patients. Methods: Forty adult patients (N = 40) newly diagnosed with HL (with no previous cancer diagnoses) and 40 healthy controls (N = 40) matched for age, sex, education, and premorbid intellect completed the neuropsychological battery and subjective and objective measures of affective distress and quality of life. Results: The results showed impairment in three out of six cognitive domains: verbal memory and learning, speed of processing/psychomotor speed, and abstraction/executive functions in the HL patients before the initiation of any treatment. The speed of processing/psychomotor speed domain is negatively correlated with depression. Conclusion: Cognitive deterioration in verbal memory and learning and abstraction/executive functions domains in HL patients seems to occur before the initiation of treatment independently of anxiety, depression, or physical symptoms. This suggests that HL itself may cause cognitive deficits in these cognitive domains. However, the underlying causes of CRCI still remain unclear. © 2023 by the authors.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

50103 - Cognitive sciences

Projekt

<a href="/cs/project/NV16-29857A" target="_blank" >NV16-29857A: Narušení kognice, strukturální a funkčně morfologické změny mozku při léčbě Hodgkinova lymfomu: translační studie.</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Current Oncology

ISSN

1198-0052

e-ISSN

1718-7729

Svazek periodika

30

Číslo periodika v rámci svazku

10

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

11

Strana od-do

9028-9038

Kód UT WoS článku

001119525500001

EID výsledku v databázi Scopus

2-s2.0-85175252435