Cognitive impairment associated with Hodgkin's lymphoma and chemotherapy

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F23%3A43921034" target="_blank" >RIV/00023752:_____/23:43921034 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/23:10454860 RIV/00216208:11120/23:43925093 RIV/00064173:_____/23:43925093

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/abs/pii/S0304394023000368?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/abs/pii/S0304394023000368?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.neulet.2023.137082" target="_blank" >10.1016/j.neulet.2023.137082</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Cognitive impairment associated with Hodgkin's lymphoma and chemotherapy

Popis výsledku v původním jazyce

Chemotherapy-related cognitive impairment (CRCI) is a well-documented side effect of cancer treatment in various types of tumors including Hodgkin’s lymphoma (HL). However, a longitudinal study evaluating the cognitive performance of HL patients has been completely lacking.The aim of the study was to determine the presence of CRCI in HL patients before, promptly after, and 6 months after treatment. Thirty-six patients newly diagnosed with HL and 45 healthy controls (HC) completed the neuropsychological battery and psychological measures of affective distress and quality of life.The results indicate that HL patients have impaired performance compared to HC which cannot be explained by emotional factors. Cognitive impairments prior to treatment were found in 3 of 6 cognitive domains, i.e., verbal memory and learning, speed of processing/psychomotor speed, and abstraction/executive function. Promptly after the chemotherapy, deficits were found in the domains of memory and learning, verbal memory, speed of processing/psychomotor speed, and abstraction/executive function. Weaker cognitive performance persist even 6 months after the end of chemotherapy, specifically in domains of verbal memory and learning, and abstraction/executive function. Our results indicate the presence of cognitive impairment in HL patients already prior to treatment and increased damages caused by chemotherapy, while some of them may last for up to 6 months after the treatment.

Název v anglickém jazyce

Cognitive impairment associated with Hodgkin's lymphoma and chemotherapy

Popis výsledku anglicky

Chemotherapy-related cognitive impairment (CRCI) is a well-documented side effect of cancer treatment in various types of tumors including Hodgkin’s lymphoma (HL). However, a longitudinal study evaluating the cognitive performance of HL patients has been completely lacking.The aim of the study was to determine the presence of CRCI in HL patients before, promptly after, and 6 months after treatment. Thirty-six patients newly diagnosed with HL and 45 healthy controls (HC) completed the neuropsychological battery and psychological measures of affective distress and quality of life.The results indicate that HL patients have impaired performance compared to HC which cannot be explained by emotional factors. Cognitive impairments prior to treatment were found in 3 of 6 cognitive domains, i.e., verbal memory and learning, speed of processing/psychomotor speed, and abstraction/executive function. Promptly after the chemotherapy, deficits were found in the domains of memory and learning, verbal memory, speed of processing/psychomotor speed, and abstraction/executive function. Weaker cognitive performance persist even 6 months after the end of chemotherapy, specifically in domains of verbal memory and learning, and abstraction/executive function. Our results indicate the presence of cognitive impairment in HL patients already prior to treatment and increased damages caused by chemotherapy, while some of them may last for up to 6 months after the treatment.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

50103 - Cognitive sciences

Projekt

<a href="/cs/project/NV16-29857A" target="_blank" >NV16-29857A: Narušení kognice, strukturální a funkčně morfologické změny mozku při léčbě Hodgkinova lymfomu: translační studie.</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Neuroscience Letters

ISSN

0304-3940

e-ISSN

1872-7972

Svazek periodika

797

Číslo periodika v rámci svazku

"Article Number: 137082"

Stát vydavatele periodika

IE - Irsko

Počet stran výsledku

6

Strana od-do

1-6

Kód UT WoS článku

000926489000001

EID výsledku v databázi Scopus

2-s2.0-85147015813