Cholinergic modulation supports dynamic switching of resting state networks through selective DMN suppression

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F24%3A43921285" target="_blank" >RIV/00023752:_____/24:43921285 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/67985807:_____/24:00586902 RIV/00023001:_____/24:00084907

Výsledek na webu

<a href="https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1012099" target="_blank" >https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1012099</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1371/journal.pcbi.1012099" target="_blank" >10.1371/journal.pcbi.1012099</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Cholinergic modulation supports dynamic switching of resting state networks through selective DMN suppression

Popis výsledku v původním jazyce

Brain activity during the resting state is widely used to examine brain organization, cognition and alterations in disease states. While it is known that neuromodulation and the state of alertness impact resting-state activity, neural mechanisms behind such modulation of resting-state activity are unknown. In this work, we used a computational model to demonstrate that change in excitability and recurrent connections, due to cholinergic modulation, impacts resting-state activity. The results of such modulation in the model match closely with experimental work on direct cholinergic modulation of Default Mode Network (DMN) in rodents. We further extended our study to the human connectome derived from diffusion-weighted MRI. In human resting-state simulations, an increase in cholinergic input resulted in a brain-wide reduction of functional connectivity. Furthermore, selective cholinergic modulation of DMN closely captured experimentally observed transitions between the baseline resting state and states with suppressed DMN fluctuations associated with attention to external tasks. Our study thus provides insight into potential neural mechanisms for the effects of cholinergic neuromodulation on resting-state activity and its dynamics.

Název v anglickém jazyce

Cholinergic modulation supports dynamic switching of resting state networks through selective DMN suppression

Popis výsledku anglicky

Brain activity during the resting state is widely used to examine brain organization, cognition and alterations in disease states. While it is known that neuromodulation and the state of alertness impact resting-state activity, neural mechanisms behind such modulation of resting-state activity are unknown. In this work, we used a computational model to demonstrate that change in excitability and recurrent connections, due to cholinergic modulation, impacts resting-state activity. The results of such modulation in the model match closely with experimental work on direct cholinergic modulation of Default Mode Network (DMN) in rodents. We further extended our study to the human connectome derived from diffusion-weighted MRI. In human resting-state simulations, an increase in cholinergic input resulted in a brain-wide reduction of functional connectivity. Furthermore, selective cholinergic modulation of DMN closely captured experimentally observed transitions between the baseline resting state and states with suppressed DMN fluctuations associated with attention to external tasks. Our study thus provides insight into potential neural mechanisms for the effects of cholinergic neuromodulation on resting-state activity and its dynamics.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30103 - Neurosciences (including psychophysiology)

Projekt

<a href="/cs/project/GA21-32608S" target="_blank" >GA21-32608S: Charakterizace stavového repertoáru a dynamiky spontánní mozkové aktivity neurozobrazovacími metodami</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

PLoS Computational Biology

ISSN

1553-734X

e-ISSN

1553-7358

Svazek periodika

20

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

26

Strana od-do

"Article Number e1012099"

Kód UT WoS článku

001241870900005

EID výsledku v databázi Scopus

2-s2.0-85195496067