EEG alpha reactivity on eyes opening discriminates patients with schizophrenia and schizoaffective disorder

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F24%3A43921363" target="_blank" >RIV/00023752:_____/24:43921363 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11120/24:43926886

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/abs/pii/S1388245724000671" target="_blank" >https://www.sciencedirect.com/science/article/abs/pii/S1388245724000671</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.clinph.2024.03.003" target="_blank" >10.1016/j.clinph.2024.03.003</a>

Jazyk výsledku

angličtina

Název v původním jazyce

EEG alpha reactivity on eyes opening discriminates patients with schizophrenia and schizoaffective disorder

Popis výsledku v původním jazyce

Objective: Alpha activity in the electroencephalogram (EEG) is typically dominant during rest with closed eyes but suppressed by visual stimulation. Previous research has shown that alpha-blockade is less pronounced in schizophrenia patients compared to healthy individuals, but no studies have examined it in schizoaffective disorder. Methods: A resting state EEG was used for the analysis of the alpha-reactivity between the eyes closed and the eyes opened conditions in overall (8 – 13 Hz), low (8 – 10 Hz) and high (10 – 13 Hz) alpha bands in three groups: schizophrenia patients (SC, n = 30), schizoaffective disorder (SA, n = 30), and healthy controls (HC, n = 36). All patients had their first psychotic episode and were receiving antipsychotic therapy. Results: A significant decrease in alpha power was noted across all subjects from the eyes-closed to eyes-open condition, spanning all regions. Alpha reactivity over the posterior regions was lower in SC compared to HC within overall and high alpha. SA showed a trend towards reduced alpha reactivity compared to HC, especially evident over the left posterior region within the overall alpha. Alpha reactivity was more pronounced over the middle and right posterior regions of SA as compared to SC, particularly in the high alpha. Alpha reactivity in SC and SA patients was associated with various negative symptoms. Conclusions: Our findings imply distinct alterations in arousal mechanisms in SC and SA and their relation to negative symptomatology. Arousal is more preserved in SA. Significance: This study is the first to compare the EEG features of arousal in SC and SA.

Název v anglickém jazyce

EEG alpha reactivity on eyes opening discriminates patients with schizophrenia and schizoaffective disorder

Popis výsledku anglicky

Objective: Alpha activity in the electroencephalogram (EEG) is typically dominant during rest with closed eyes but suppressed by visual stimulation. Previous research has shown that alpha-blockade is less pronounced in schizophrenia patients compared to healthy individuals, but no studies have examined it in schizoaffective disorder. Methods: A resting state EEG was used for the analysis of the alpha-reactivity between the eyes closed and the eyes opened conditions in overall (8 – 13 Hz), low (8 – 10 Hz) and high (10 – 13 Hz) alpha bands in three groups: schizophrenia patients (SC, n = 30), schizoaffective disorder (SA, n = 30), and healthy controls (HC, n = 36). All patients had their first psychotic episode and were receiving antipsychotic therapy. Results: A significant decrease in alpha power was noted across all subjects from the eyes-closed to eyes-open condition, spanning all regions. Alpha reactivity over the posterior regions was lower in SC compared to HC within overall and high alpha. SA showed a trend towards reduced alpha reactivity compared to HC, especially evident over the left posterior region within the overall alpha. Alpha reactivity was more pronounced over the middle and right posterior regions of SA as compared to SC, particularly in the high alpha. Alpha reactivity in SC and SA patients was associated with various negative symptoms. Conclusions: Our findings imply distinct alterations in arousal mechanisms in SC and SA and their relation to negative symptomatology. Arousal is more preserved in SA. Significance: This study is the first to compare the EEG features of arousal in SC and SA.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30103 - Neurosciences (including psychophysiology)

Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Clinical Neurophysiology

ISSN

1388-2457

e-ISSN

1872-8952

Svazek periodika

161

Číslo periodika v rámci svazku

May

Stát vydavatele periodika

IE - Irsko

Počet stran výsledku

11

Strana od-do

211-221

Kód UT WoS článku

001218437500001

EID výsledku v databázi Scopus

2-s2.0-85188665184