Orgasms, sexual pleasure, and opioid reward mechanisms

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F25%3A43921574" target="_blank" >RIV/00023752:_____/25:43921574 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11240/25:10512323

Výsledek na webu

<a href="https://academic.oup.com/smr/article/13/3/381/8127191" target="_blank" >https://academic.oup.com/smr/article/13/3/381/8127191</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/sxmrev/qeaf023" target="_blank" >10.1093/sxmrev/qeaf023</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Orgasms, sexual pleasure, and opioid reward mechanisms

Popis výsledku v původním jazyce

Introduction: Sexual activity produces pleasure related to sexual arousal, desire, and genitosensory and erogenous stimulation. Orgasmsproduce a whole brain and body rush of ecstatic pleasure followed by relaxation and refractoriness. This pleasure results from the activation ofneurochemical reward pathways in the brain. This is differentiated by spinal pathways that control climax, the particular motor movements ofthe pelvic floor and the experience of tension release.Objectives: To relate the activation of key neurochemical reward and bonding systems, notably dopamine, oxytocin, and opioids, to the pleasureof sexual activity in general and orgasms in particular.Methods: A narrative review of the neurochemical and neuroanatomical mechanisms activated during sexual stimulation and orgasm in rats andhumans, and how they are related overall to the generation of sexual pleasure and reward.Results: Appetitive sexual pleasure involves the activation of dopamine and oxytocin release in hypothalamic and mesolimbic regions thatregulate sexual arousal and desire, and are reinforced by localized opioid activity. Orgasms are thought to result in part from a massive releaseof opioids into these regions that inhibits dopamine and oxytocin transmission, but that initiates molecular changes to sensitize both systemsand induce sexually conditioned place and partner preferences. Serotonin is also activated at orgasm and contributes to feelings of satietyand refractoriness. Orgasm disorders are distressing, cause resentment and conflict in a relationship, and diminish overall sexual health andwell-being.Conclusions: Orgasms are an important component of sexual pleasure for humans and perhaps all vertebrates. Endogenous opioids like βendorphin that bind to mu opioid receptors are likely responsible for sexual pleasure and reward.

Název v anglickém jazyce

Orgasms, sexual pleasure, and opioid reward mechanisms

Popis výsledku anglicky

Introduction: Sexual activity produces pleasure related to sexual arousal, desire, and genitosensory and erogenous stimulation. Orgasmsproduce a whole brain and body rush of ecstatic pleasure followed by relaxation and refractoriness. This pleasure results from the activation ofneurochemical reward pathways in the brain. This is differentiated by spinal pathways that control climax, the particular motor movements ofthe pelvic floor and the experience of tension release.Objectives: To relate the activation of key neurochemical reward and bonding systems, notably dopamine, oxytocin, and opioids, to the pleasureof sexual activity in general and orgasms in particular.Methods: A narrative review of the neurochemical and neuroanatomical mechanisms activated during sexual stimulation and orgasm in rats andhumans, and how they are related overall to the generation of sexual pleasure and reward.Results: Appetitive sexual pleasure involves the activation of dopamine and oxytocin release in hypothalamic and mesolimbic regions thatregulate sexual arousal and desire, and are reinforced by localized opioid activity. Orgasms are thought to result in part from a massive releaseof opioids into these regions that inhibits dopamine and oxytocin transmission, but that initiates molecular changes to sensitize both systemsand induce sexually conditioned place and partner preferences. Serotonin is also activated at orgasm and contributes to feelings of satietyand refractoriness. Orgasm disorders are distressing, cause resentment and conflict in a relationship, and diminish overall sexual health andwell-being.Conclusions: Orgasms are an important component of sexual pleasure for humans and perhaps all vertebrates. Endogenous opioids like βendorphin that bind to mu opioid receptors are likely responsible for sexual pleasure and reward.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30103 - Neurosciences (including psychophysiology)

Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Sexual Medicine Reviews

ISSN

2050-0513

e-ISSN

2050-0521

Svazek periodika

13

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

13

Strana od-do

381-393

Kód UT WoS článku

001484112700001

EID výsledku v databázi Scopus

2-s2.0-105010374586