Effects of in vitro fertilization and intracytoplasmic sperm injection treatment on female patients' perinatal mental health: systematic review and meta-analysis

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F25%3A43921658" target="_blank" >RIV/00023752:_____/25:43921658 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/25:10503887 RIV/00216208:11120/25:43928951 RIV/00216208:11130/25:10503887 RIV/00216208:11210/25:10503887 RIV/00216208:11310/25:10503887

Výsledek na webu

<a href="https://www.frontiersin.org/journals/reproductive-health/articles/10.3389/frph.2025.1668831/full" target="_blank" >https://www.frontiersin.org/journals/reproductive-health/articles/10.3389/frph.2025.1668831/full</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3389/frph.2025.1668831" target="_blank" >10.3389/frph.2025.1668831</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Effects of in vitro fertilization and intracytoplasmic sperm injection treatment on female patients' perinatal mental health: systematic review and meta-analysis

Popis výsledku v původním jazyce

Introduction: In vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) patients often experience stress, which exacerbates the burden associated with infertility and may lead to an increased risk of mental-health difficulties. In this systematic review and meta-analysis, we examined the effects of IVF or ICSI on female patients&apos; mental health. Methods: A database search was conducted in PubMed, Web of Science, and PsychInfo to select relevant studies. Forty-four studies involving 858,966 participants were included in the systematic review. The results of these studies were very heterogeneous and yielded contradictory findings. Two meta-analyses, comprising a total of seven studies, were conducted. The first calculated the standardized mean difference of symptoms of depression between women who became pregnant through IVF and those who conceived spontaneously. In the second, we compared symptoms of anxiety between these two groups. Results: Five studies examined depressive symptoms and showed no significant difference between the two groups: SMD = -.15; 95% CI [-.33,.03], p = .10. A meta-analysis of six studies on anxiety symptoms revealed significantly higher levels in the IVF groups compared to the controls: SMD = .33; 95% CI [.17,.49], p &lt; .001. Discussion: The results suggest that the psychological effects of IVF/ICSI, especially with respect to anxiety, require attention and support from healthcare providers, although the effect size is small. Further studies with adequate sample sizes, including women with both successful and unsuccessful treatment, and adequately controlling for important confounders are needed to fully understand the effects of IVF/ICSI on mental health.

Název v anglickém jazyce

Effects of in vitro fertilization and intracytoplasmic sperm injection treatment on female patients' perinatal mental health: systematic review and meta-analysis

Popis výsledku anglicky

Introduction: In vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) patients often experience stress, which exacerbates the burden associated with infertility and may lead to an increased risk of mental-health difficulties. In this systematic review and meta-analysis, we examined the effects of IVF or ICSI on female patients&apos; mental health. Methods: A database search was conducted in PubMed, Web of Science, and PsychInfo to select relevant studies. Forty-four studies involving 858,966 participants were included in the systematic review. The results of these studies were very heterogeneous and yielded contradictory findings. Two meta-analyses, comprising a total of seven studies, were conducted. The first calculated the standardized mean difference of symptoms of depression between women who became pregnant through IVF and those who conceived spontaneously. In the second, we compared symptoms of anxiety between these two groups. Results: Five studies examined depressive symptoms and showed no significant difference between the two groups: SMD = -.15; 95% CI [-.33,.03], p = .10. A meta-analysis of six studies on anxiety symptoms revealed significantly higher levels in the IVF groups compared to the controls: SMD = .33; 95% CI [.17,.49], p &lt; .001. Discussion: The results suggest that the psychological effects of IVF/ICSI, especially with respect to anxiety, require attention and support from healthcare providers, although the effect size is small. Further studies with adequate sample sizes, including women with both successful and unsuccessful treatment, and adequately controlling for important confounders are needed to fully understand the effects of IVF/ICSI on mental health.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30304 - Public and environmental health

Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Frontiers in Reproductive Health

ISSN

2673-3153

e-ISSN

2673-3153

Svazek periodika

7

Číslo periodika v rámci svazku

"Article Number 1668831"

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

23

Strana od-do

1-23

Kód UT WoS článku

001588883600001

EID výsledku v databázi Scopus

2-s2.0-105018723053