Changes of BMI, steroid metabolome and psychopathology in patients with anorexia nervosa during hospitalization

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023761%3A_____%2F20%3AN0000004" target="_blank" >RIV/00023761:_____/20:N0000004 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/20:10399754 RIV/00216208:11120/20:43918907 RIV/00064165:_____/20:10399754

Výsledek na webu

<a href="https://reader.elsevier.com/reader/sd/pii/S0039128X19302132?token=4F96B81483853A407C2B0F5AAB9E4733CDBD499A412353D28A43742D182AF4704C33ED6476BFE8FFC73CB83C29902D40" target="_blank" >https://reader.elsevier.com/reader/sd/pii/S0039128X19302132?token=4F96B81483853A407C2B0F5AAB9E4733CDBD499A412353D28A43742D182AF4704C33ED6476BFE8FFC73CB83C29902D40</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Changes of BMI, steroid metabolome and psychopathology in patients with anorexia nervosa during hospitalization

Popis výsledku v původním jazyce

Anorexia nervosa (AN) is associated with various alterations including the dysfunction of the HPA axis and consequently the hypercortisolemia and deficit in sex hormones but the comprehensive evaluation of changes in circulating steroids during the hospitalization of AN patients is lacking. We investigated the effect of realimentation of women with AN during hospitalization on 45 circulating steroids, the relationships between BMI, its change during hospitalization and physical activity, on one side and initial levels and their changes for two adipokines, circulating steroids, anorexia-specific (hunger, appetite and satiety), and anorexia non-specific symptoms (anxiety, depression fatigue, sleep, and body pain) on the other side. We included 33 women with anorexia who were hospitalized for 38 (35, 44) days (median with quartiles). The increase of BMI from the initial value 15.2 (13.2, 16.6) kg/m(2) was 1.69 (1.37, 2.66) kg/m(2). The patients with more severe anorexia showed higher activity in 7 beta-, and 16 alpha-hydroxylation of androgen precursors, which declined during hospitalization. Otherwise, the 7 alpha-hydroxylation activity is higher in AN patients with less severe malnutrition and the ratio of 5-androstene-3 beta,7 alpha,17 beta-triol to 5-androstene-3j3,7]3,17|3-triol increased during the realimentation. Our data allow to speculate that the intensive 7 beta-, and 16 alpha- and possibly also the 7 alpha-hydroxylation of C19 Delta(5) steroids participate in the pathophysiology of anorexia by additional catabolism of substrates available for synthesis of active androgens and estrogens. However, the question remains whether the synthetic analogues of 7 alpha/beta- and 16 alpha-hydroxy-steroids prevent the catabolism of the sex steroid precursors, or further activate the "energy wasting" mitochondrial thermogenic metabolism.

Název v anglickém jazyce

Changes of BMI, steroid metabolome and psychopathology in patients with anorexia nervosa during hospitalization

Popis výsledku anglicky

Anorexia nervosa (AN) is associated with various alterations including the dysfunction of the HPA axis and consequently the hypercortisolemia and deficit in sex hormones but the comprehensive evaluation of changes in circulating steroids during the hospitalization of AN patients is lacking. We investigated the effect of realimentation of women with AN during hospitalization on 45 circulating steroids, the relationships between BMI, its change during hospitalization and physical activity, on one side and initial levels and their changes for two adipokines, circulating steroids, anorexia-specific (hunger, appetite and satiety), and anorexia non-specific symptoms (anxiety, depression fatigue, sleep, and body pain) on the other side. We included 33 women with anorexia who were hospitalized for 38 (35, 44) days (median with quartiles). The increase of BMI from the initial value 15.2 (13.2, 16.6) kg/m(2) was 1.69 (1.37, 2.66) kg/m(2). The patients with more severe anorexia showed higher activity in 7 beta-, and 16 alpha-hydroxylation of androgen precursors, which declined during hospitalization. Otherwise, the 7 alpha-hydroxylation activity is higher in AN patients with less severe malnutrition and the ratio of 5-androstene-3 beta,7 alpha,17 beta-triol to 5-androstene-3j3,7]3,17|3-triol increased during the realimentation. Our data allow to speculate that the intensive 7 beta-, and 16 alpha- and possibly also the 7 alpha-hydroxylation of C19 Delta(5) steroids participate in the pathophysiology of anorexia by additional catabolism of substrates available for synthesis of active androgens and estrogens. However, the question remains whether the synthetic analogues of 7 alpha/beta- and 16 alpha-hydroxy-steroids prevent the catabolism of the sex steroid precursors, or further activate the "energy wasting" mitochondrial thermogenic metabolism.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

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OECD FORD obor

10608 - Biochemistry and molecular biology

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Steroids

ISSN

0039-128X

e-ISSN

1878-5867

Svazek periodika

153

Číslo periodika v rámci svazku

January

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

10

Strana od-do

nestrankovano

Kód UT WoS článku

000509615100010

EID výsledku v databázi Scopus

2-s2.0-85074053048