Radiosurgery of brain cavernomas - long-term results

Kód výsledku v IS VaVaI

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Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Radiosurgery of brain cavernomas - long-term results

Popis výsledku v původním jazyce

The radiosurgery of cavernomas remains a controversial issue. The only way to verify the positive effect of the treatment is by clinical observation during a longer follow up period, where the decreased annual risk of rebleeding should be observed after the latent interval inherent to radiosurgery. Besides this, an improvement in clinical symptoms (e.g. secondary epilepsy) and regression of the treated lesion might also be observed. In a group of 112 patients with brain cavernomas treated in our centre between 1992 2000 with the marginal dose of median 16 Gy the risk of bleeding decreased from 2% before the treatment to 0,5% after 2 years latent interval (median follow up 84 months). A decrease of the cavernoma was observed in 53% of cases and an increase in 6.4%. Epilepsy, if present before the treatment, improved in 45% of cases. Risk of temporary and permanent morbidity caused by radiosurgery was 14.6% and 0.9% respectively. This morbidity can be reduced by a lower marginal dose and future studies should show if repeated radiosurgery decreases the risks from natural course of the disease in those cases where the initial radiosurgery failed.

Název v anglickém jazyce

Radiosurgery of brain cavernomas - long-term results

Popis výsledku anglicky

The radiosurgery of cavernomas remains a controversial issue. The only way to verify the positive effect of the treatment is by clinical observation during a longer follow up period, where the decreased annual risk of rebleeding should be observed after the latent interval inherent to radiosurgery. Besides this, an improvement in clinical symptoms (e.g. secondary epilepsy) and regression of the treated lesion might also be observed. In a group of 112 patients with brain cavernomas treated in our centre between 1992 2000 with the marginal dose of median 16 Gy the risk of bleeding decreased from 2% before the treatment to 0,5% after 2 years latent interval (median follow up 84 months). A decrease of the cavernoma was observed in 53% of cases and an increase in 6.4%. Epilepsy, if present before the treatment, improved in 45% of cases. Risk of temporary and permanent morbidity caused by radiosurgery was 14.6% and 0.9% respectively. This morbidity can be reduced by a lower marginal dose and future studies should show if repeated radiosurgery decreases the risks from natural course of the disease in those cases where the initial radiosurgery failed.

Druh

C - Kapitola v odborné knize

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

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Projekt

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Návaznosti

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Gamma knife radiosurgery for brain vascular malformations

ISBN

978-3-8055-9619-0

Počet stran výsledku

10

Strana od-do

147-156

Počet stran knihy

232

Název nakladatele

Karger

Místo vydání

Basel

Kód UT WoS kapitoly

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