FDG-PET/CT lymph node staging after neoadjuvant chemotherapy in patients with adenocarcinoma of the esophageal gastric junction

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023884%3A_____%2F16%3A%230006809" target="_blank" >RIV/00023884:_____/16:#0006809 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/16:10327735 RIV/00064203:_____/16:10327735 RIV/00064165:_____/16:10327735

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

FDG-PET/CT lymph node staging after neoadjuvant chemotherapy in patients with adenocarcinoma of the esophageal gastric junction

Popis výsledku v původním jazyce

Objectives: The aim of the analysis was to assess the accuracy of various FDG-PET/CT parameters in staging lymph nodes after neoadjuvant chemotherapy. Methods: In this prospective study, 74 patients with adenocarcinoma of the esophageal gastric junction were examined by FDG-PET/CT in the course of their neoadjuvant chemotherapy given before surgical treatment. Data from the final FDG-PET/CT examinations were compared with the histology from the surgical specimens (gold standard). The accuracy was calculated for four FDG-PET/CT parameters: (1) hypermetabolic nodes, (2) large nodes, (3) large-and-medium large nodes, and (4) hypermetabolic or large nodes. Results: In 74 patients, a total of 1540 lymph nodes were obtained by surgery, and thesewere grouped into 287 regions according to topographic origin. Five hundred and two nodes were imaged byFDG-PET/CT andwere grouped into these same regions for comparison. In the analysis, (1) hypermetabolic nodes, (2) large nodes, (3) large-and medium large nodes, and (4) hypermetabolic or large nodes identified metastases in particular regions with sensitivities of 11.6%, 2.9%, 21.7%, and 13.0%, respectively; specificity was 98.6%, 94.5%, 74.8%, and 93.6%, respectively. The best accuracy of 77.7%reached the parameter of hypermetabolic nodes.Accuracy decreased to 62.0% whenalso smaller nodes (medium-large) were taken for the parameter of metastases. Conclusions: FDG-PET/CT proved low sensitivity and high specificity. Low sensitivity was based on low detection rate (32.6%) when compared nodes imaged by FDG-PET/CT to nodes found by surgery, and in inability to detect micrometastases. Sensitivity increased when also medium-large LNs were taken for positive, but specificity and accuracy decreased.

Název v anglickém jazyce

FDG-PET/CT lymph node staging after neoadjuvant chemotherapy in patients with adenocarcinoma of the esophageal gastric junction

Popis výsledku anglicky

Objectives: The aim of the analysis was to assess the accuracy of various FDG-PET/CT parameters in staging lymph nodes after neoadjuvant chemotherapy. Methods: In this prospective study, 74 patients with adenocarcinoma of the esophageal gastric junction were examined by FDG-PET/CT in the course of their neoadjuvant chemotherapy given before surgical treatment. Data from the final FDG-PET/CT examinations were compared with the histology from the surgical specimens (gold standard). The accuracy was calculated for four FDG-PET/CT parameters: (1) hypermetabolic nodes, (2) large nodes, (3) large-and-medium large nodes, and (4) hypermetabolic or large nodes. Results: In 74 patients, a total of 1540 lymph nodes were obtained by surgery, and thesewere grouped into 287 regions according to topographic origin. Five hundred and two nodes were imaged byFDG-PET/CT andwere grouped into these same regions for comparison. In the analysis, (1) hypermetabolic nodes, (2) large nodes, (3) large-and medium large nodes, and (4) hypermetabolic or large nodes identified metastases in particular regions with sensitivities of 11.6%, 2.9%, 21.7%, and 13.0%, respectively; specificity was 98.6%, 94.5%, 74.8%, and 93.6%, respectively. The best accuracy of 77.7%reached the parameter of hypermetabolic nodes.Accuracy decreased to 62.0% whenalso smaller nodes (medium-large) were taken for the parameter of metastases. Conclusions: FDG-PET/CT proved low sensitivity and high specificity. Low sensitivity was based on low detection rate (32.6%) when compared nodes imaged by FDG-PET/CT to nodes found by surgery, and in inability to detect micrometastases. Sensitivity increased when also medium-large LNs were taken for positive, but specificity and accuracy decreased.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

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Projekt

<a href="/cs/project/NT12331" target="_blank" >NT12331: Časné hodnocení efektivity neoadjuvantní chemoterapie u karcinomu jícnu a ezofago-gastrické junkce pomocí FDG-PET/CT vyšetření.</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Abdominal Radiology

ISSN

2366-004X

e-ISSN

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Svazek periodika

41

Číslo periodika v rámci svazku

11

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

6

Strana od-do

2089-2094

Kód UT WoS článku

000385183500001

EID výsledku v databázi Scopus

2-s2.0-84978091932