The relationship between brain abnormalities and autistic psychopathology in pervasive developmental disorders

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023884%3A_____%2F21%3A00009136" target="_blank" >RIV/00023884:_____/21:00009136 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/21:10427996 RIV/00064203:_____/21:10427996 RIV/00216208:11130/21:10427996 RIV/00216224:14210/21:00122010

Výsledek na webu

<a href="https://jab.zsf.jcu.cz/artkey/jab-202102-0002_the-relationship-between-brain-abnormalities-and-autistic-psychopathology-in-pervasive-developmental-disorders.php" target="_blank" >https://jab.zsf.jcu.cz/artkey/jab-202102-0002_the-relationship-between-brain-abnormalities-and-autistic-psychopathology-in-pervasive-developmental-disorders.php</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.32725/jab.2021.009" target="_blank" >10.32725/jab.2021.009</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The relationship between brain abnormalities and autistic psychopathology in pervasive developmental disorders

Popis výsledku v původním jazyce

The aim of the present research has been to determine whether there is a relationship between brain abnormalities found on magnetic resonance imaging (MRI) and autistic psychopathology. A retrospective analysis covering a period between 1998 and 2015 induded 489 children with autism (404 boys, 85 girls; average age 8.0 +/- 4.2 years) who underwent an MRI of the brain. For dinical diagnosis of autism, the International Classification of Diseases, 10th revision (ICD-10), was used. Autistic psychopathology was evaluated by means of the Autism Diagnostic Interview - Revised. The Spearman nonparametric correlation analysis and chi-square test were used to examine the possible relationships between variables. The group of autistic children did not manifest a statistically significant correlation between the parameters examined on MRI and autistic psychopathology. A correlation between other cysts and repetitive behavior was significant only at trend level (P = 0.054). Gliosis of the brain was significantly more frequent in autistic children with mental retardation than in children without mental retardation (14.1% vs. 7.4%; P = 0.028). Nonmyelinated areas in the brain were significantly more frequent in autistic children with autistic regression than in children without autistic regression (29.9% vs. 15.7%; P = 0.008). Mental retardation was significantly more frequent in autistic children with autistic regression than in children without regression (73.2% vs. 52.5%; P = 0.002). Our research study did not reveal a statistically significant correlation of brain abnormalities on MRI with autistic psychopathology.

Název v anglickém jazyce

The relationship between brain abnormalities and autistic psychopathology in pervasive developmental disorders

Popis výsledku anglicky

The aim of the present research has been to determine whether there is a relationship between brain abnormalities found on magnetic resonance imaging (MRI) and autistic psychopathology. A retrospective analysis covering a period between 1998 and 2015 induded 489 children with autism (404 boys, 85 girls; average age 8.0 +/- 4.2 years) who underwent an MRI of the brain. For dinical diagnosis of autism, the International Classification of Diseases, 10th revision (ICD-10), was used. Autistic psychopathology was evaluated by means of the Autism Diagnostic Interview - Revised. The Spearman nonparametric correlation analysis and chi-square test were used to examine the possible relationships between variables. The group of autistic children did not manifest a statistically significant correlation between the parameters examined on MRI and autistic psychopathology. A correlation between other cysts and repetitive behavior was significant only at trend level (P = 0.054). Gliosis of the brain was significantly more frequent in autistic children with mental retardation than in children without mental retardation (14.1% vs. 7.4%; P = 0.028). Nonmyelinated areas in the brain were significantly more frequent in autistic children with autistic regression than in children without autistic regression (29.9% vs. 15.7%; P = 0.008). Mental retardation was significantly more frequent in autistic children with autistic regression than in children without regression (73.2% vs. 52.5%; P = 0.002). Our research study did not reveal a statistically significant correlation of brain abnormalities on MRI with autistic psychopathology.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30224 - Radiology, nuclear medicine and medical imaging

Projekt

<a href="/cs/project/NV18-04-00085" target="_blank" >NV18-04-00085: Význam maternálních autoprotilátek při vzniku poruch autistického spektra</a><br>

Návaznosti

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal Of Applied Biomedicine

ISSN

1214-021X

e-ISSN

—

Svazek periodika

19

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

6

Strana od-do

91-96

Kód UT WoS článku

000649173600002

EID výsledku v databázi Scopus

2-s2.0-85107001799