Comparative study evaluating a new dose optimization software for Gamma Knife treatment planning – comparison of 80 challenging treatment plans

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023884%3A_____%2F25%3A00010071" target="_blank" >RIV/00023884:_____/25:00010071 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68407700:21340/25:00388769

Výsledek na webu

<a href="https://karger.com/sfn/article-abstract/doi/10.1159/000546214/927815/Comparative-study-evaluating-a-new-dose?redirectedFrom=fulltext" target="_blank" >https://karger.com/sfn/article-abstract/doi/10.1159/000546214/927815/Comparative-study-evaluating-a-new-dose?redirectedFrom=fulltext</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1159/000546214" target="_blank" >10.1159/000546214</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Comparative study evaluating a new dose optimization software for Gamma Knife treatment planning – comparison of 80 challenging treatment plans

Popis výsledku v původním jazyce

Introduction In 2020, Elekta Instrument AB, Stockholm, released a new dose optimizer for Leksell GammaPlan, which includes the possibility of inverse planning. This study aimed to compare the new software with the previous manual version of treatment planning for stereotactic neurosurgery and evaluate its performance. Materials and Methods Four types of diagnoses — vestibular schwannomas, pituitary adenomas, meningiomas, and single brain metastasis — along with 80 clinically approved challenging cases, were selected for testing the new software. Key parameters, including coverage, selectivity, target volume, and doses to critical structures, were collected and statistically analyzed using a t-test. These parameters were compared based on the Leksell Gamma Knife Society standardization document for stereotactic radiosurgery, both for each diagnosis and for the entire dataset. Results The new software showed a clear advantage, particularly in sparing critical structures while maintaining or improving treatment plan conformity. Doses to critical structures such as the optic nerve, brainstem, cochlea, and pituitary gland decreased by an average of 13% (0.76 Gy), 7% (0.52 Gy), 7% (0.2 Gy), and 14% (1.04 Gy), respectively, reducing toxicity. Other plan parameters also showed significant improvements, except for the gradient index. Selectivity improved by 11% (0.03), the Shaw Conformity Index improved by 10% (0.1), and coverage improved by 0.01. Additionally, treatment time was reduced by 10% enhancing patient comfort. Conclusion Overall, Leksell Gamma Knife Lightning is faster and produces treatment plans with superior parameters compared to manual planning.

Název v anglickém jazyce

Comparative study evaluating a new dose optimization software for Gamma Knife treatment planning – comparison of 80 challenging treatment plans

Popis výsledku anglicky

Introduction In 2020, Elekta Instrument AB, Stockholm, released a new dose optimizer for Leksell GammaPlan, which includes the possibility of inverse planning. This study aimed to compare the new software with the previous manual version of treatment planning for stereotactic neurosurgery and evaluate its performance. Materials and Methods Four types of diagnoses — vestibular schwannomas, pituitary adenomas, meningiomas, and single brain metastasis — along with 80 clinically approved challenging cases, were selected for testing the new software. Key parameters, including coverage, selectivity, target volume, and doses to critical structures, were collected and statistically analyzed using a t-test. These parameters were compared based on the Leksell Gamma Knife Society standardization document for stereotactic radiosurgery, both for each diagnosis and for the entire dataset. Results The new software showed a clear advantage, particularly in sparing critical structures while maintaining or improving treatment plan conformity. Doses to critical structures such as the optic nerve, brainstem, cochlea, and pituitary gland decreased by an average of 13% (0.76 Gy), 7% (0.52 Gy), 7% (0.2 Gy), and 14% (1.04 Gy), respectively, reducing toxicity. Other plan parameters also showed significant improvements, except for the gradient index. Selectivity improved by 11% (0.03), the Shaw Conformity Index improved by 10% (0.1), and coverage improved by 0.01. Additionally, treatment time was reduced by 10% enhancing patient comfort. Conclusion Overall, Leksell Gamma Knife Lightning is faster and produces treatment plans with superior parameters compared to manual planning.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30103 - Neurosciences (including psychophysiology)

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Stereotactic and Functional Neurosurgery

ISSN

1011-6125

e-ISSN

—

Svazek periodika

103

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

10

Strana od-do

269-278

Kód UT WoS článku

001521942300001

EID výsledku v databázi Scopus

2-s2.0-105010246169