Spatial navigation deficits in early Alzheimer's disease: the role of biomarkers and APOE genotype

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023884%3A_____%2F25%3A00010216" target="_blank" >RIV/00023884:_____/25:00010216 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064203:_____/25:10498658 RIV/00216208:11210/25:10498658 RIV/00216208:11130/25:10498658

Výsledek na webu

<a href="https://link.springer.com/article/10.1007/s00415-025-13151-8" target="_blank" >https://link.springer.com/article/10.1007/s00415-025-13151-8</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00415-025-13151-8" target="_blank" >10.1007/s00415-025-13151-8</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Spatial navigation deficits in early Alzheimer's disease: the role of biomarkers and APOE genotype

Popis výsledku v původním jazyce

Spatial navigation deficits are early symptoms of Alzheimer's disease (AD). The apolipoprotein E (APOE) epsilon 4 allele is the most important genetic risk factor for AD. This study investigated effects of APOE genotype on spatial navigation in biomarker-defined individuals with amnestic mild cognitive impairment (aMCI) and associations of AD biomarkers and atrophy of AD-related brain regions with spatial navigation.Methods107 participants, cognitively normal older adults (CN, n = 48) and aMCI individuals stratified into AD aMCI (n = 28) and non-AD aMCI (n = 31) groups, underwent cognitive assessment, brain MRI, and spatial navigation assessment using the Virtual Supermarket Test with egocentric and allocentric tasks and a self-report questionnaire. Cerebrospinal fluid (CSF) biomarkers (amyloid-beta 1-42, phosphorylated tau181 and total tau) and amyloid PET imaging were assessed in aMCI participants.ResultsAD aMCI participants had the highest prevalence of APOE epsilon 4 carriers and worst allocentric navigation. CSF levels of AD biomarkers and atrophy in AD-related brain regions were associated with worse allocentric navigation. Between-group differences in spatial navigation and associations with AD biomarkers and regional brain atrophy were not influenced by APOE genotype. Self-reported navigation ability was similar across groups and unrelated to spatial navigation performance.ConclusionsThese findings suggest that allocentric navigation deficits in aMCI individuals are predominantly driven by AD pathology, independent of APOE genotype. This highlights the role of AD pathology as measured by biomarkers, rather than genetic status, as a major factor in navigational impairment in aMCI, and emphasizes the assessment of spatial navigation as a valuable tool for early detection of AD.

Název v anglickém jazyce

Spatial navigation deficits in early Alzheimer's disease: the role of biomarkers and APOE genotype

Popis výsledku anglicky

Spatial navigation deficits are early symptoms of Alzheimer's disease (AD). The apolipoprotein E (APOE) epsilon 4 allele is the most important genetic risk factor for AD. This study investigated effects of APOE genotype on spatial navigation in biomarker-defined individuals with amnestic mild cognitive impairment (aMCI) and associations of AD biomarkers and atrophy of AD-related brain regions with spatial navigation.Methods107 participants, cognitively normal older adults (CN, n = 48) and aMCI individuals stratified into AD aMCI (n = 28) and non-AD aMCI (n = 31) groups, underwent cognitive assessment, brain MRI, and spatial navigation assessment using the Virtual Supermarket Test with egocentric and allocentric tasks and a self-report questionnaire. Cerebrospinal fluid (CSF) biomarkers (amyloid-beta 1-42, phosphorylated tau181 and total tau) and amyloid PET imaging were assessed in aMCI participants.ResultsAD aMCI participants had the highest prevalence of APOE epsilon 4 carriers and worst allocentric navigation. CSF levels of AD biomarkers and atrophy in AD-related brain regions were associated with worse allocentric navigation. Between-group differences in spatial navigation and associations with AD biomarkers and regional brain atrophy were not influenced by APOE genotype. Self-reported navigation ability was similar across groups and unrelated to spatial navigation performance.ConclusionsThese findings suggest that allocentric navigation deficits in aMCI individuals are predominantly driven by AD pathology, independent of APOE genotype. This highlights the role of AD pathology as measured by biomarkers, rather than genetic status, as a major factor in navigational impairment in aMCI, and emphasizes the assessment of spatial navigation as a valuable tool for early detection of AD.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30103 - Neurosciences (including psychophysiology)

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Neurology

ISSN

0340-5354

e-ISSN

—

Svazek periodika

272

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

24

Strana od-do

—

Kód UT WoS článku

001500448500001

EID výsledku v databázi Scopus

2-s2.0-105007289791