The Combined Effect of APOE and BDNF Va166Met Polymorphisms on Spatial Navigation in Older Adults

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F20%3A00073526" target="_blank" >RIV/00159816:_____/20:00073526 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00023884:_____/20:00008778

Výsledek na webu

<a href="https://content.iospress.com/articles/journal-of-alzheimers-disease/jad200615" target="_blank" >https://content.iospress.com/articles/journal-of-alzheimers-disease/jad200615</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3233/JAD-200615" target="_blank" >10.3233/JAD-200615</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The Combined Effect of APOE and BDNF Va166Met Polymorphisms on Spatial Navigation in Older Adults

Popis výsledku v původním jazyce

Background: The apolipoprotein E (APOE) epsilon 4 allele is associated with episodic memory and spatial navigation deficits. The brain-derived neurotrophic factor (BDNF) Met allele may further worsen memory impairment in APOE epsilon 4 carriers but its role in APOE epsilon 4-related spatial navigation deficits has not been established. Objective: We examined influence of APOE and BDNF Va166Met polymorphism combination on spatial navigation and volumes of selected navigation-related brain regions in cognitively unimpaired (CU) older adults and those with amnestic mild cognitive impairment (aMCI). Methods: 187 participants (aMCI [n = 116] and CU [n=71]) from the Czech Brain Aging Study were stratified based on APOE and BDNF Va166Met polymorphisms into four groups: epsilon 4(-)/BDNFval/val, epsilon 4(-)/BDNFMet, epsilon 4(+)/BDNFval/val, and epsilon 4(+)/BDNFMet The participants underwent comprehensive neuropsychological examination, brain MRI, and spatial navigation testing of egocentric, allocentric, and allocentric delayed navigation in a real-space human analogue of the Morris water maze. Results: Among the aMCI participants, the epsilon 4(+)/BDNFMet group had the least accurate egocentric navigation performance (p &lt; 0.05) and lower verbal memory performance than the epsilon 4(-)/BDNFval/val group (p = 0.007). The epsilon 4(+)/BDNFMet group had smaller hippocampal and entorhinal cortical volumes than the epsilon 4(-)/BDNFval/val (p &lt;= 0.019) and epsilon 4(-)/BDNFMet (p &lt;= 0.020) groups. Among the CU participants, the epsilon 4(+)/BDNFMet group had less accurate allocentric and allocentric delayed navigation performance than the epsilon 4(-)/BDNFval/val group (p &lt; 0.05). Conclusion: The combination of APOE epsilon 4 and BDNF Met polymorphisms is associated with more pronounced egocentric navigation impairment and atrophy of the medial temporal lobe regions in individuals with aMCI and less accurate allocentric navigation in CU older adults.

Název v anglickém jazyce

The Combined Effect of APOE and BDNF Va166Met Polymorphisms on Spatial Navigation in Older Adults

Popis výsledku anglicky

Background: The apolipoprotein E (APOE) epsilon 4 allele is associated with episodic memory and spatial navigation deficits. The brain-derived neurotrophic factor (BDNF) Met allele may further worsen memory impairment in APOE epsilon 4 carriers but its role in APOE epsilon 4-related spatial navigation deficits has not been established. Objective: We examined influence of APOE and BDNF Va166Met polymorphism combination on spatial navigation and volumes of selected navigation-related brain regions in cognitively unimpaired (CU) older adults and those with amnestic mild cognitive impairment (aMCI). Methods: 187 participants (aMCI [n = 116] and CU [n=71]) from the Czech Brain Aging Study were stratified based on APOE and BDNF Va166Met polymorphisms into four groups: epsilon 4(-)/BDNFval/val, epsilon 4(-)/BDNFMet, epsilon 4(+)/BDNFval/val, and epsilon 4(+)/BDNFMet The participants underwent comprehensive neuropsychological examination, brain MRI, and spatial navigation testing of egocentric, allocentric, and allocentric delayed navigation in a real-space human analogue of the Morris water maze. Results: Among the aMCI participants, the epsilon 4(+)/BDNFMet group had the least accurate egocentric navigation performance (p &lt; 0.05) and lower verbal memory performance than the epsilon 4(-)/BDNFval/val group (p = 0.007). The epsilon 4(+)/BDNFMet group had smaller hippocampal and entorhinal cortical volumes than the epsilon 4(-)/BDNFval/val (p &lt;= 0.019) and epsilon 4(-)/BDNFMet (p &lt;= 0.020) groups. Among the CU participants, the epsilon 4(+)/BDNFMet group had less accurate allocentric and allocentric delayed navigation performance than the epsilon 4(-)/BDNFval/val group (p &lt; 0.05). Conclusion: The combination of APOE epsilon 4 and BDNF Met polymorphisms is associated with more pronounced egocentric navigation impairment and atrophy of the medial temporal lobe regions in individuals with aMCI and less accurate allocentric navigation in CU older adults.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30103 - Neurosciences (including psychophysiology)

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Alzheimers Disease

ISSN

1387-2877

e-ISSN

—

Svazek periodika

78

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

20

Strana od-do

1473-1492

Kód UT WoS článku

000596593800016

EID výsledku v databázi Scopus

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