Functional and Structural Similarity Between Insect and Human Hearts: Electrocardiography of Insect Hearts for Screening of New Cardioactive Drugs

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027006%3A_____%2F13%3A00002818" target="_blank" >RIV/00027006:_____/13:00002818 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Functional and Structural Similarity Between Insect and Human Hearts: Electrocardiography of Insect Hearts for Screening of New Cardioactive Drugs

Popis výsledku v původním jazyce

The primordial formation of insect and human hearts is orchestrated by similar sets of genes. The rhythmicity of purely myogenic, peristaltic myocardial contractions of insect heart is determined by a posterior pacemaker nodus, which is analogous to sinoatrial or atrioventricular pacemaker nodi of the human heart. Insects are very mobile animals; there are vigorous neuromuscular contractions and extracardiac pulsations in haemocoelic pressure, which may seriously interfere with recordings of the heartbeat. This problem was solved by using larvae of the waxmoth, whose neuromuscular functions were totally paralysed by proteinaceous venom of the parasitic braconid wasp. The paralysed larvae survived motionless for 3 to 4 weeks, however, the regular myogenic pulsations of the heart and intestine, regulated by depolarisation potentials of the myocardial or intestinal cells, remained fully preserved. The paralysed larvae of the waxmoth are ideal object for cardiological research. By means of

Název v anglickém jazyce

Functional and Structural Similarity Between Insect and Human Hearts: Electrocardiography of Insect Hearts for Screening of New Cardioactive Drugs

Popis výsledku anglicky

The primordial formation of insect and human hearts is orchestrated by similar sets of genes. The rhythmicity of purely myogenic, peristaltic myocardial contractions of insect heart is determined by a posterior pacemaker nodus, which is analogous to sinoatrial or atrioventricular pacemaker nodi of the human heart. Insects are very mobile animals; there are vigorous neuromuscular contractions and extracardiac pulsations in haemocoelic pressure, which may seriously interfere with recordings of the heartbeat. This problem was solved by using larvae of the waxmoth, whose neuromuscular functions were totally paralysed by proteinaceous venom of the parasitic braconid wasp. The paralysed larvae survived motionless for 3 to 4 weeks, however, the regular myogenic pulsations of the heart and intestine, regulated by depolarisation potentials of the myocardial or intestinal cells, remained fully preserved. The paralysed larvae of the waxmoth are ideal object for cardiological research. By means of

Druh

D - Stať ve sborníku

CEP obor

FA - Kardiovaskulární nemoci včetně kardiochirurgie

OECD FORD obor

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Projekt

<a href="/cs/project/QJ1310057" target="_blank" >QJ1310057: Technologie řízených atmosfér a teplotních manipulací, proti škůdcům skladovaných obilovin</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Proceedings from Cardiotechnik 2013

ISBN

978-989-8565-78-5

ISSN

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e-ISSN

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Počet stran výsledku

8

Strana od-do

5-12

Název nakladatele

IOP Publishing Ltd

Místo vydání

Bristol

Místo konání akce

Algarve, Portugal

Datum konání akce

1. 1. 2013

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

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