Neuromuscular paralysis induced in insect larvae by the proteinic venom of a parasitic wasp

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F12%3A00376139" target="_blank" >RIV/60077344:_____/12:00376139 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Neuromuscular paralysis induced in insect larvae by the proteinic venom of a parasitic wasp

Popis výsledku v původním jazyce

Larvae of the greater wax moth (Galleria mellonella), stung by a tiny 2.5 mm long Habrobracon hebetor wasp, become immobilised within a few minutes and remain completely paralysed for several weeks. Paralysed larvae are absolutely motionless, flaccid, without internal pressure, serving as a source of food for the parasite. The venom is a relatively large proteinic molecule, its size has been estimated by various authors from 17 to 73 kDa, and the largest fraction has been partly sequenced. The mode of action is generally ascribed to the inhibition of neuromuscular transmission. Purely myogenic systems driven by depolarisation potentials of the muscle or myocardium cells (heart, intestine) or junctional potencials of the sympathetic nerves (glands, excretory organs), remain intact and fully functional. Using recently invented, touch-free electrocardiographic (ECG) techniques, we found that the heartbeat of paralysed larvae was regulated by a purely myogenic mechanism with a pacemaker no

Název v anglickém jazyce

Neuromuscular paralysis induced in insect larvae by the proteinic venom of a parasitic wasp

Popis výsledku anglicky

Larvae of the greater wax moth (Galleria mellonella), stung by a tiny 2.5 mm long Habrobracon hebetor wasp, become immobilised within a few minutes and remain completely paralysed for several weeks. Paralysed larvae are absolutely motionless, flaccid, without internal pressure, serving as a source of food for the parasite. The venom is a relatively large proteinic molecule, its size has been estimated by various authors from 17 to 73 kDa, and the largest fraction has been partly sequenced. The mode of action is generally ascribed to the inhibition of neuromuscular transmission. Purely myogenic systems driven by depolarisation potentials of the muscle or myocardium cells (heart, intestine) or junctional potencials of the sympathetic nerves (glands, excretory organs), remain intact and fully functional. Using recently invented, touch-free electrocardiographic (ECG) techniques, we found that the heartbeat of paralysed larvae was regulated by a purely myogenic mechanism with a pacemaker no

Druh

C - Kapitola v odborné knize

CEP obor

ED - Fyziologie

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Advances in Medicine and Biology. Volume 43

ISBN

978-1-62100-889-7

Počet stran výsledku

18

Strana od-do

195-212

Počet stran knihy

301

Název nakladatele

Nova Science Publishers

Místo vydání

New York

Kód UT WoS kapitoly

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