Induced pluripotent stem (iPS) cells in domestic animals recent achievements - a review

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027014%3A_____%2F13%3A%230001852" target="_blank" >RIV/00027014:_____/13:#0001852 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.vuzv.cz/sites/File/_privat/13083.pdf" target="_blank" >http://www.vuzv.cz/sites/File/_privat/13083.pdf</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Induced pluripotent stem (iPS) cells in domestic animals recent achievements - a review

Popis výsledku v původním jazyce

Pluripotent cells show the unlimited self-renewal capacity and the potential to differentiate into the cell lineages originating from three germ layers. To date real pluripotent stem cell lines, able to generate germ line chimeras, have been establishedin rodents. Large domestic animals, especially pig, due to their considerable anatomical and physiological similarities with humans are thought to be convenient model to test potential of pluripotent cells in cell replacement therapy before their clinical use. However, creating pluripotent cells in domestic animals until now has met the limitations due to lack of evidence for germ line contribution. Therefore they can not be considered real pluripotent cells but rather putative embryonic or embryonic-like stem cells. Recently, much attention has been drawn to the reprogramming technologies which enable redirection of differentiated somatic cells to the pluripotent status. The aim of this review is to present the recent achievements in g

Název v anglickém jazyce

Induced pluripotent stem (iPS) cells in domestic animals recent achievements - a review

Popis výsledku anglicky

Pluripotent cells show the unlimited self-renewal capacity and the potential to differentiate into the cell lineages originating from three germ layers. To date real pluripotent stem cell lines, able to generate germ line chimeras, have been establishedin rodents. Large domestic animals, especially pig, due to their considerable anatomical and physiological similarities with humans are thought to be convenient model to test potential of pluripotent cells in cell replacement therapy before their clinical use. However, creating pluripotent cells in domestic animals until now has met the limitations due to lack of evidence for germ line contribution. Therefore they can not be considered real pluripotent cells but rather putative embryonic or embryonic-like stem cells. Recently, much attention has been drawn to the reprogramming technologies which enable redirection of differentiated somatic cells to the pluripotent status. The aim of this review is to present the recent achievements in g

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Animal Science Papers and Reports

ISSN

0860-4037

e-ISSN

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Svazek periodika

31

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

PL - Polská republika

Počet stran výsledku

11

Strana od-do

89-99

Kód UT WoS článku

000320487100001

EID výsledku v databázi Scopus

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