Comparative study of the hypocholesterolemic and hypolipidemic activity of alginate and amidated alginate in rats

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027014%3A_____%2F17%3AN0000180" target="_blank" >RIV/00027014:_____/17:N0000180 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60460709:41210/17:74116 RIV/60460709:41340/17:75637

Výsledek na webu

<a href="https://vuzv.cz/_privat/17177.pdf" target="_blank" >https://vuzv.cz/_privat/17177.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ijbiomac.2017.07.077" target="_blank" >10.1016/j.ijbiomac.2017.07.077</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Comparative study of the hypocholesterolemic and hypolipidemic activity of alginate and amidated alginate in rats

Popis výsledku v původním jazyce

Alginate is a copolymer of beta-D-mannuronate and alfa-L-guluronate, which are present in the cell wall of brown algae. The hypocholesterolemic and hypolipidemic activities of alginate and its derivative,which is prepared by a reaction with octadecylamine, were compared in rats fed diets containing cholesterol and palm fat at 10 and 50 g/kg, respectively. Amidated alginate at 20 g/kg significantly decreased serum cholesterol from 2.93 to 2.00 mikromol/mL, serum triacylglycerols from 1.66 to 0.92 mikromol/mL, hepatic cholesterol from 17.5 to 5.9 mikromol/g, and total hepatic lipids from 67.4 to 51.7 mg/g. Alginate at 20 g/kg significantly reduced hepatic cholesterol to 13.1 mikromol/g, but did not influence serum cholesterol, triacyl-glycerols, and total hepatic lipids. Amidated alginate significantly increased the faecal concentrations of neutral sterols from 98.7 to 122.4 mikromol/g DM, but decreased faecal concentration of bile acids from 19.4 to 14.0 mikromol/g DM. In samples of intestinal contents, taurine-conjugated bile acids dominated glycineconjugates. The supplementation of diets with cholesterol significantly increased the expression of hepatic cholesterol 7 alfa-hydroxylase, especially in rats that received cholesterol without alginate or amidatedalginate. In conclusion, amidated alginate is an effective hypocholesterolemic agent that is more efficient than its parent polysaccharide.

Název v anglickém jazyce

Comparative study of the hypocholesterolemic and hypolipidemic activity of alginate and amidated alginate in rats

Popis výsledku anglicky

Alginate is a copolymer of beta-D-mannuronate and alfa-L-guluronate, which are present in the cell wall of brown algae. The hypocholesterolemic and hypolipidemic activities of alginate and its derivative,which is prepared by a reaction with octadecylamine, were compared in rats fed diets containing cholesterol and palm fat at 10 and 50 g/kg, respectively. Amidated alginate at 20 g/kg significantly decreased serum cholesterol from 2.93 to 2.00 mikromol/mL, serum triacylglycerols from 1.66 to 0.92 mikromol/mL, hepatic cholesterol from 17.5 to 5.9 mikromol/g, and total hepatic lipids from 67.4 to 51.7 mg/g. Alginate at 20 g/kg significantly reduced hepatic cholesterol to 13.1 mikromol/g, but did not influence serum cholesterol, triacyl-glycerols, and total hepatic lipids. Amidated alginate significantly increased the faecal concentrations of neutral sterols from 98.7 to 122.4 mikromol/g DM, but decreased faecal concentration of bile acids from 19.4 to 14.0 mikromol/g DM. In samples of intestinal contents, taurine-conjugated bile acids dominated glycineconjugates. The supplementation of diets with cholesterol significantly increased the expression of hepatic cholesterol 7 alfa-hydroxylase, especially in rats that received cholesterol without alginate or amidatedalginate. In conclusion, amidated alginate is an effective hypocholesterolemic agent that is more efficient than its parent polysaccharide.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10608 - Biochemistry and molecular biology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

International Journal of Biological Macromolecules

ISSN

0141-8130

e-ISSN

—

Svazek periodika

105

Číslo periodika v rámci svazku

není

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

5

Strana od-do

620-624

Kód UT WoS článku

000414882900069

EID výsledku v databázi Scopus

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