Long-term hypocholesterolemic effect of amidated alginate in rats

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027014%3A_____%2F18%3AN0000197" target="_blank" >RIV/00027014:_____/18:N0000197 - isvavai.cz</a>

Výsledek na webu

<a href="https://vuzv.cz/_privat/18196.pdf" target="_blank" >https://vuzv.cz/_privat/18196.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.15407/ubj90.06.120" target="_blank" >10.15407/ubj90.06.120</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Long-term hypocholesterolemic effect of amidated alginate in rats

Popis výsledku v původním jazyce

The effect of octadecylamide of alginic acid on blood serum and hepatic cholesterol, and the faecal output of fat and sterols was examined in female rats fed diets containing cholesterol and palm fat at 10 and 50 g/kg, respectively for 10 weeks. Amidated alginate, supplied at 10 and 20 g/kg, significantly decreased serum cholesterol from 5.25 to 2.99 and 2.39 μmol/ml, respectively, and decreased hepatic cholesterol from 30.7 to 12.3 and 9.4 μmol/g, respectively. Amidated alginate increased the faecal output of fat and at higher dosing significantly decreased faecal output of bile acids. Faecal output of bile acids and hepatic cholesterol significantly correlated (r = 0.791; P < 0.001). The results of the present experiment showed that hypocholesterolemic effect of amidated alginate persisted within 10 weeks of feeding.

Název v anglickém jazyce

Long-term hypocholesterolemic effect of amidated alginate in rats

Popis výsledku anglicky

The effect of octadecylamide of alginic acid on blood serum and hepatic cholesterol, and the faecal output of fat and sterols was examined in female rats fed diets containing cholesterol and palm fat at 10 and 50 g/kg, respectively for 10 weeks. Amidated alginate, supplied at 10 and 20 g/kg, significantly decreased serum cholesterol from 5.25 to 2.99 and 2.39 μmol/ml, respectively, and decreased hepatic cholesterol from 30.7 to 12.3 and 9.4 μmol/g, respectively. Amidated alginate increased the faecal output of fat and at higher dosing significantly decreased faecal output of bile acids. Faecal output of bile acids and hepatic cholesterol significantly correlated (r = 0.791; P < 0.001). The results of the present experiment showed that hypocholesterolemic effect of amidated alginate persisted within 10 weeks of feeding.

Druh

J_SC - Článek v periodiku v databázi SCOPUS

CEP obor

—

OECD FORD obor

10608 - Biochemistry and molecular biology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Ukrainian biochemical journal

ISSN

2409-4943

e-ISSN

—

Svazek periodika

90

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

UA - Ukrajina

Počet stran výsledku

6

Strana od-do

120-125

Kód UT WoS článku

—

EID výsledku v databázi Scopus

2-s2.0-85057302712