Function of atypical mammalian oocyte/zygote nucleoli and its implications for reproductive biology and medicine

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027014%3A_____%2F19%3AN0000053" target="_blank" >RIV/00027014:_____/19:N0000053 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1387/ijdb.180329jf" target="_blank" >http://dx.doi.org/10.1387/ijdb.180329jf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1387/ijdb.180329jf" target="_blank" >10.1387/ijdb.180329jf</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Function of atypical mammalian oocyte/zygote nucleoli and its implications for reproductive biology and medicine

Popis výsledku v původním jazyce

Mammalian oocytes/zygotes contain atypical nucleoli that are composed exclusively of a dense fibrillar material. It has been commonly accepted that these nucleoli serve as a repository of components that are used later on, as the embryo develops, for the construction of typical tripartite nucleoli. Indeed, when nucleoli were removed from immature oocytes (enucleolation) and these oocytes were then matured, fertilized or parthenogenetically activated, development of the produced embryos ceased after one or two cleavages with no detectable nucleoli in nuclei. This indicated that zygotic nucleoli originate exclusively from oocytes, i.e. are maternally inherited. Recently published results, however, do not support this developmental biology dogma and demonstrate that maternal nucleoli in one-cell stage embryos are necessary only during a very short time period after fertilization when they serve as a major heterochromatin organizing structures. Nevertheless, it still remains to be determined, which other functions/roles the atypical oocyte/zygote nucleoli eventually have.

Název v anglickém jazyce

Function of atypical mammalian oocyte/zygote nucleoli and its implications for reproductive biology and medicine

Popis výsledku anglicky

Mammalian oocytes/zygotes contain atypical nucleoli that are composed exclusively of a dense fibrillar material. It has been commonly accepted that these nucleoli serve as a repository of components that are used later on, as the embryo develops, for the construction of typical tripartite nucleoli. Indeed, when nucleoli were removed from immature oocytes (enucleolation) and these oocytes were then matured, fertilized or parthenogenetically activated, development of the produced embryos ceased after one or two cleavages with no detectable nucleoli in nuclei. This indicated that zygotic nucleoli originate exclusively from oocytes, i.e. are maternally inherited. Recently published results, however, do not support this developmental biology dogma and demonstrate that maternal nucleoli in one-cell stage embryos are necessary only during a very short time period after fertilization when they serve as a major heterochromatin organizing structures. Nevertheless, it still remains to be determined, which other functions/roles the atypical oocyte/zygote nucleoli eventually have.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10604 - Reproductive biology (medical aspects to be 3)

Projekt

<a href="/cs/project/GA17-08605S" target="_blank" >GA17-08605S: Jaderné a cytoplasmatické determinanty zodpovědné za regulaci zrání oocytů a vývoj embrya</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

International Journal of Developmental Biology

ISSN

0214-6282

e-ISSN

—

Svazek periodika

63

Číslo periodika v rámci svazku

3-5

Stát vydavatele periodika

ES - Španělské království

Počet stran výsledku

8

Strana od-do

105-112

Kód UT WoS článku

000464941000005

EID výsledku v databázi Scopus

2-s2.0-85065655521