Chapter 15 - Nuclear Transfer Technology and Its Use in Reproductive Medicine

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027014%3A_____%2F21%3AN0000254" target="_blank" >RIV/00027014:_____/21:N0000254 - isvavai.cz</a>

Výsledek na webu

<a href="https://vuzv.cz/_privat/21245.pdf" target="_blank" >https://vuzv.cz/_privat/21245.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1017/9781108887595" target="_blank" >10.1017/9781108887595</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Chapter 15 - Nuclear Transfer Technology and Its Use in Reproductive Medicine

Popis výsledku v původním jazyce

This chapter focuses on the application of nuclear transfer for production of “artificial gametes”, through the haploidization of somatic cells transplanted into immature (germinal vesicle, GV) or mature (metaphase II) oocytes. Haploidization of somatic nuclei through their transfer into oocytes from human, or model mammals has been attempted already with predominantly negative outcomes. In this chapter we critically review the published reports on the topic, with the conclusion that induction of a “totipotent” state to the somatic cell nuclei prior to haploidization has never been taken into consideration. The message our chapter conveys is that advancements in knowledge of in vitro somatic cell reprogramming, and remodeling of somatic cells injected into “selectively enucleated germinal vesicle” (SEGV) oocytes, make realistic the production of artificial gametes through haploidization of somatic cells by nuclear transfer.

Název v anglickém jazyce

Chapter 15 - Nuclear Transfer Technology and Its Use in Reproductive Medicine

Popis výsledku anglicky

This chapter focuses on the application of nuclear transfer for production of “artificial gametes”, through the haploidization of somatic cells transplanted into immature (germinal vesicle, GV) or mature (metaphase II) oocytes. Haploidization of somatic nuclei through their transfer into oocytes from human, or model mammals has been attempted already with predominantly negative outcomes. In this chapter we critically review the published reports on the topic, with the conclusion that induction of a “totipotent” state to the somatic cell nuclei prior to haploidization has never been taken into consideration. The message our chapter conveys is that advancements in knowledge of in vitro somatic cell reprogramming, and remodeling of somatic cells injected into “selectively enucleated germinal vesicle” (SEGV) oocytes, make realistic the production of artificial gametes through haploidization of somatic cells by nuclear transfer.

Druh

C - Kapitola v odborné knize

CEP obor

—

OECD FORD obor

10604 - Reproductive biology (medical aspects to be 3)

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Manual of Intracytoplasmic Sperm Injection in Human Assisted Reproduction

ISBN

978-11-0888-759-5

Počet stran výsledku

6

Strana od-do

148-153

Počet stran knihy

196

Název nakladatele

Cambridge University Press

Místo vydání

Cambridge

Kód UT WoS kapitoly

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