Mechanisms supporting haplotype groups in mammalian TLRs

Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027014%3A_____%2F22%3AN0000225" target="_blank" >RIV/00027014:_____/22:N0000225 - isvavai.cz</a>
Výsledek na webu
<a href="https://vuzv.cz/_privat/22227.pdf" target="_blank" >https://vuzv.cz/_privat/22227.pdf</a>
DOI - Digital Object Identifier
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Jazyk výsledku
angličtina
Název v původním jazyce
Mechanisms supporting haplotype groups in mammalian TLRs
Popis výsledku v původním jazyce
The haplotype structure of anti-bacterial Toll-like receptor genes (TLR1, -2, -4, -5 and -6) in Czech Red Pied cattle was explored. Initially, single nucleotide polymorphisms were detected by hybrid resequencing that combined PacBio RSII and WGS with HiSeq X Ten. 15 haplotypes were directly revealed in TLR2 by amplicon sequences and two distinct holotype groups were detected using the Network program. Clustering in TLR2 was independently confirmed for statistically reconstructed haplotypes. The bimodal distribution was also detectable in the haplotypes of TLR5 and -6, while only a trend was seen in TLR4 and -1.
Název v anglickém jazyce
Mechanisms supporting haplotype groups in mammalian TLRs
Popis výsledku anglicky
The haplotype structure of anti-bacterial Toll-like receptor genes (TLR1, -2, -4, -5 and -6) in Czech Red Pied cattle was explored. Initially, single nucleotide polymorphisms were detected by hybrid resequencing that combined PacBio RSII and WGS with HiSeq X Ten. 15 haplotypes were directly revealed in TLR2 by amplicon sequences and two distinct holotype groups were detected using the Network program. Clustering in TLR2 was independently confirmed for statistically reconstructed haplotypes. The bimodal distribution was also detectable in the haplotypes of TLR5 and -6, while only a trend was seen in TLR4 and -1.

Projekt
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Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění
2022
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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