Antimicrobial polyhydroxybutyrate submicron fiber mat loaded with extract of Hypericum perforatum

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027022%3A_____%2F21%3AN0000001" target="_blank" >RIV/00027022:_____/21:N0000001 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Antimicrobial polyhydroxybutyrate submicron fiber mat loaded with extract of Hypericum perforatum

Popis výsledku v původním jazyce

Milos Beran, Ales Horna, Viktor Vorisek, Eliska Berkova, Radka Korinkova, Vojtech Trousil, Marketa Hrubanova. Invited lecture: Antimicrobial polyhydroxybutyrate submicron fiber mat loaded with extract of Hypericum perforatum. The European Advanced Materials Congress. 23-25 August 2021, Stockholm, Sweden. The aim of this work was to prepare a new biodegradable polyhydroxybutyrate submicron fiber mat loaded with Hypericum perforatum hypericin rich raw extract by centrifugal spinning technology, an alternative approach to fabricate nanofibers or microfibers from solutions at high speed and low cost. Hypericins in methanol/aceton extract of H. perforatum were determined by UHPLC-MS/MS and HPLC/PDA methods. Pure PHB and the H. perforatum extract enriched PHB submicron fiber mats were prepared using a pilot plant demonstrator for the centrifugal spinning technology and characterized by SEM. Singlet oxygen production was quantified by the 1,3-diphenylisobenzofuran method in hexan. The results proved a significant production of singlet oxygen by the prepared submicron fiber mat. We have also found a very significant antibacterial activity against Escherichia coli CCM 5417 bacterial strain by a method in accordance with JIS Z 2801 / ISO 22196 tests. Determination of antiviral activities of the submicron fiber mats with H. perforatum extract against enveloped virus is in progress. The H. perforatum extract enriched PHB submicron fiber mats showed potential in development of self-cleaning and antimicrobial air filters.

Název v anglickém jazyce

Antimicrobial polyhydroxybutyrate submicron fiber mat loaded with extract of Hypericum perforatum

Popis výsledku anglicky

Milos Beran, Ales Horna, Viktor Vorisek, Eliska Berkova, Radka Korinkova, Vojtech Trousil, Marketa Hrubanova. Invited lecture: Antimicrobial polyhydroxybutyrate submicron fiber mat loaded with extract of Hypericum perforatum. The European Advanced Materials Congress. 23-25 August 2021, Stockholm, Sweden. The aim of this work was to prepare a new biodegradable polyhydroxybutyrate submicron fiber mat loaded with Hypericum perforatum hypericin rich raw extract by centrifugal spinning technology, an alternative approach to fabricate nanofibers or microfibers from solutions at high speed and low cost. Hypericins in methanol/aceton extract of H. perforatum were determined by UHPLC-MS/MS and HPLC/PDA methods. Pure PHB and the H. perforatum extract enriched PHB submicron fiber mats were prepared using a pilot plant demonstrator for the centrifugal spinning technology and characterized by SEM. Singlet oxygen production was quantified by the 1,3-diphenylisobenzofuran method in hexan. The results proved a significant production of singlet oxygen by the prepared submicron fiber mat. We have also found a very significant antibacterial activity against Escherichia coli CCM 5417 bacterial strain by a method in accordance with JIS Z 2801 / ISO 22196 tests. Determination of antiviral activities of the submicron fiber mats with H. perforatum extract against enveloped virus is in progress. The H. perforatum extract enriched PHB submicron fiber mats showed potential in development of self-cleaning and antimicrobial air filters.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

21001 - Nano-materials (production and properties)

Projekt

<a href="/cs/project/TH03020466" target="_blank" >TH03020466: Inovované zařízení a technologie pro průmyslovou výrobu nanovláken vyfukováním z roztoků.</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů