Asociace episodického znečištění ovzduší se vzrůstem DNA fragmentace v lidských spermiích bez dalších změn v kvalitě semene

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F05%3A06000011" target="_blank" >RIV/00027162:_____/05:06000011 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Episodic air pollution is associated with increased DNA fragmentation in human sperm without other changes in semen quality

Popis výsledku v původním jazyce

This study examined potential associations between exposure to episodes of air pollution and alterations in semen quality. The air pollution, resulting from combustion of coal for industry and home heating in the Teplice, was much higher during thewinterthan at other times of year. Young men from Teplice were sampled up to seven times over two years allowing evaluation of semen quality after periods of exposure to both low and high air pollution. Routine semen analysis and tests for spermaneuploidy andchromatin integrity were performed, comparing measurements within each man. Using repeated measures analysis, a significant association was found between exposure to periods of high air pollution and the percentage of sperm with DNAfragmentation according to Sperm Chromatin Structure Assay. Exposure to intermittent air pollution may result in sperm DNA damage and thereby increase the rates of male-mediated infertility, miscarriage, and other adverse reproductive outcomes.

Název v anglickém jazyce

Episodic air pollution is associated with increased DNA fragmentation in human sperm without other changes in semen quality

Popis výsledku anglicky

This study examined potential associations between exposure to episodes of air pollution and alterations in semen quality. The air pollution, resulting from combustion of coal for industry and home heating in the Teplice, was much higher during thewinterthan at other times of year. Young men from Teplice were sampled up to seven times over two years allowing evaluation of semen quality after periods of exposure to both low and high air pollution. Routine semen analysis and tests for spermaneuploidy andchromatin integrity were performed, comparing measurements within each man. Using repeated measures analysis, a significant association was found between exposure to periods of high air pollution and the percentage of sperm with DNAfragmentation according to Sperm Chromatin Structure Assay. Exposure to intermittent air pollution may result in sperm DNA damage and thereby increase the rates of male-mediated infertility, miscarriage, and other adverse reproductive outcomes.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

DN - Vliv životního prostředí na zdraví

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2005

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Human Reproduction

ISSN

0268-1161

e-ISSN

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Svazek periodika

20

Číslo periodika v rámci svazku

10

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

8

Strana od-do

2776-2783

Kód UT WoS článku

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EID výsledku v databázi Scopus

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