Impakt PCB na estrogenní aktivitu v lidském mužském séru

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F05%3A06000061" target="_blank" >RIV/00027162:_____/05:06000061 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68081707:_____/05:00022140 RIV/00216208:11160/05:00007037

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Impact of Polychlorinated Biphenyls Contamination on Estrogenic Activity in Human Male Serum

Popis výsledku v původním jazyce

The ER-CALUX and DR-CALUX bioassays were used for determination of estrogenic/antiestrogenic and dioxin-like activities of prevalent PCB congeners and PCB mixtures isolated from human male serum. Low-molecular-weight PCBs were estrogenic, while theprevalent higher chlorinated PCB congeners (PCBs 138, 153, 170, 180, 187, 194, 199, and 203) as well as major PCB metabolites were antiestrogenic. In the male serum extracts collected from residents of area with an extensive PCB contamination, highlevels of PCBs were associated with a decreased ER-mediated activity and an increased dioxin-like activity. 17beta-Estradiol was responsible for major part of of estrogenic activity` our data seem to suggest that in might be important to pay attention todirect effects of PCBs on steroid hormone levels. Nondioxin-like PCBs were responsible for the weak antiestrogenic activity of some fractions containing only persistent organic pollutants.

Název v anglickém jazyce

Impact of Polychlorinated Biphenyls Contamination on Estrogenic Activity in Human Male Serum

Popis výsledku anglicky

The ER-CALUX and DR-CALUX bioassays were used for determination of estrogenic/antiestrogenic and dioxin-like activities of prevalent PCB congeners and PCB mixtures isolated from human male serum. Low-molecular-weight PCBs were estrogenic, while theprevalent higher chlorinated PCB congeners (PCBs 138, 153, 170, 180, 187, 194, 199, and 203) as well as major PCB metabolites were antiestrogenic. In the male serum extracts collected from residents of area with an extensive PCB contamination, highlevels of PCBs were associated with a decreased ER-mediated activity and an increased dioxin-like activity. 17beta-Estradiol was responsible for major part of of estrogenic activity` our data seem to suggest that in might be important to pay attention todirect effects of PCBs on steroid hormone levels. Nondioxin-like PCBs were responsible for the weak antiestrogenic activity of some fractions containing only persistent organic pollutants.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

DN - Vliv životního prostředí na zdraví

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2005

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Environmental Health Perspectives

ISSN

0091-6765

e-ISSN

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Svazek periodika

113

Číslo periodika v rámci svazku

10

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

8

Strana od-do

1277-1284

Kód UT WoS článku

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EID výsledku v databázi Scopus

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