Estrogenní, antiestrogenní a dioxinové aktivity ve vzorcích lidských mužských sér z východního Slovenska

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F08%3A%230000471" target="_blank" >RIV/00027162:_____/08:#0000471 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Estrogenic, Antiestroegnic, and Dioxin-Like Activities in Human Male Serum Samples from Eastern Slovakia

Popis výsledku v původním jazyce

Polychlorinated biphenyls (PCBs) are thought to cause numerous adverse health effects, but their impact on estrogen signaling is still not fully understood. In the present study, we used the ER-CALUX bioassay to determine estrogenic/antiestrogenic activities of the prevalent PCB congeners and PCB mixtures isolated from human male serum. The samples were collected from residents of an area with an extensive environmental contamination from a former PCB production site as well as from a neighboring background region in eastern Slovakia. We found that the lowerchlorinated PCBs were estrogenic, whereas the prevalent higher-chlorinated PCB congeners 138, 153, 170, 180, 187, 194, 199, and 203, as well as major PCB metabolites, behaved as antiestrogens. 17 beta-Estradiol (E2) was responsible for a major part of estrogenic activity identified in total serum extracts.

Název v anglickém jazyce

Estrogenic, Antiestroegnic, and Dioxin-Like Activities in Human Male Serum Samples from Eastern Slovakia

Popis výsledku anglicky

Polychlorinated biphenyls (PCBs) are thought to cause numerous adverse health effects, but their impact on estrogen signaling is still not fully understood. In the present study, we used the ER-CALUX bioassay to determine estrogenic/antiestrogenic activities of the prevalent PCB congeners and PCB mixtures isolated from human male serum. The samples were collected from residents of an area with an extensive environmental contamination from a former PCB production site as well as from a neighboring background region in eastern Slovakia. We found that the lowerchlorinated PCBs were estrogenic, whereas the prevalent higher-chlorinated PCB congeners 138, 153, 170, 180, 187, 194, 199, and 203, as well as major PCB metabolites, behaved as antiestrogens. 17 beta-Estradiol (E2) was responsible for a major part of estrogenic activity identified in total serum extracts.

Druh

C - Kapitola v odborné knize

CEP obor

DN - Vliv životního prostředí na zdraví

OECD FORD obor

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Projekt

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Návaznosti

R - Projekt Ramcoveho programu EK

Rok uplatnění

2008

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

PCBs Human and Environmental Disposition and Toxicology

ISBN

978-0-252-03254-7

Počet stran výsledku

12

Strana od-do

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Počet stran knihy

216

Název nakladatele

University of Illinois

Místo vydání

Illinois, USA

Kód UT WoS kapitoly

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