Dexamethazonem indukovaná imunosuprese - králičí model

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F08%3A%230000344" target="_blank" >RIV/00027162:_____/08:#0000344 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Dexamethasone-induced immunosuppression: a rabbit model

Popis výsledku v původním jazyce

The aim of this study was to characterize a model of immunosuppression in rabbits, based on changes in the lymphocyte subset distribution and changes in proliferative capacity of lymphocytes 1, 3 and 7 days after the administration of 2 mg/kg dexamethasone phosphate (DXP) three times at 6-h intervals. In blood, neutrophilia and lymphopenia without leukocytosis was detected. One day after DXP administration the absolute numbers of all lymphocyte subsets decreased in the blood, whereas in bone marrow, absolute numbers of all lymphocyte subsets increased significantly. In the thymus, DXP led to a marked reduction of numbers of CD4+CD8+ thymocytes. The proliferative capacity of lymphocytes was lower in the blood and spleen only on day 1, no changes were detected in lymph nodes or in bone marrow. The results demonstrate that this DXP application protocol is useful for the experimental induction of short-lasting immunosuppression in rabbits.

Název v anglickém jazyce

Dexamethasone-induced immunosuppression: a rabbit model

Popis výsledku anglicky

The aim of this study was to characterize a model of immunosuppression in rabbits, based on changes in the lymphocyte subset distribution and changes in proliferative capacity of lymphocytes 1, 3 and 7 days after the administration of 2 mg/kg dexamethasone phosphate (DXP) three times at 6-h intervals. In blood, neutrophilia and lymphopenia without leukocytosis was detected. One day after DXP administration the absolute numbers of all lymphocyte subsets decreased in the blood, whereas in bone marrow, absolute numbers of all lymphocyte subsets increased significantly. In the thymus, DXP led to a marked reduction of numbers of CD4+CD8+ thymocytes. The proliferative capacity of lymphocytes was lower in the blood and spleen only on day 1, no changes were detected in lymph nodes or in bone marrow. The results demonstrate that this DXP application protocol is useful for the experimental induction of short-lasting immunosuppression in rabbits.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

GJ - Choroby a škůdci zvířat, veterinární medicina

OECD FORD obor

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Projekt

<a href="/cs/project/GA524%2F05%2F2714" target="_blank" >GA524/05/2714: Infekce králíků Pasteurella multocida séroskupin A a F</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2008

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Veterinary Immunology and Immunopathology

ISSN

0165-2427

e-ISSN

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Svazek periodika

122

Číslo periodika v rámci svazku

3-4

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

10

Strana od-do

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Kód UT WoS článku

000255325600004

EID výsledku v databázi Scopus

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