Vývoj lymfatických orgánů u králíků: hlavní lymfocytární subpopulace

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F07%3A%230000194" target="_blank" >RIV/00027162:_____/07:#0000194 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Lymphoid organ development in rabbits: Major lymphocyte subsets

Popis výsledku v původním jazyce

In the present study, rabbit lymphocyte subsets in peripheral blood, spleen, mesenteric and popliteal lymph nodes in newborn and 2-, 4-, 6- and 8-week old and adult animals were characterized. Lymphocyte subsets were detected using flow cytometry and monoclonal antibodies against rabbit CD4, CD8, T-cell-specific antigen and cross-reactive antibody against B-cell antigen CD79alpha. In neonates, lower numbers of T cells were detected in both peripheral blood and spleen than in mesenteric lymph nodes. In comparison with other compartments, CD79alpha+ cells prevailed in the spleen. Postnatal development was characterized by a decreased CD4+/CD8+ ratio due to increasing frequency of CD8+ lymphocytes in all organs but mesenteric lymph nodes, where it was dueto decreased numbers of CD4+ lymphocytes. Another significant feature was the increase of B cells in peripheral blood and mesenteric lymph nodes.

Název v anglickém jazyce

Lymphoid organ development in rabbits: Major lymphocyte subsets

Popis výsledku anglicky

In the present study, rabbit lymphocyte subsets in peripheral blood, spleen, mesenteric and popliteal lymph nodes in newborn and 2-, 4-, 6- and 8-week old and adult animals were characterized. Lymphocyte subsets were detected using flow cytometry and monoclonal antibodies against rabbit CD4, CD8, T-cell-specific antigen and cross-reactive antibody against B-cell antigen CD79alpha. In neonates, lower numbers of T cells were detected in both peripheral blood and spleen than in mesenteric lymph nodes. In comparison with other compartments, CD79alpha+ cells prevailed in the spleen. Postnatal development was characterized by a decreased CD4+/CD8+ ratio due to increasing frequency of CD8+ lymphocytes in all organs but mesenteric lymph nodes, where it was dueto decreased numbers of CD4+ lymphocytes. Another significant feature was the increase of B cells in peripheral blood and mesenteric lymph nodes.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

GJ - Choroby a škůdci zvířat, veterinární medicina

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2007

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Developmental and Comparative Immunology

ISSN

0145-305X

e-ISSN

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Svazek periodika

31

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

13

Strana od-do

632-644

Kód UT WoS článku

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EID výsledku v databázi Scopus

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