Raný postnatální vývoj imunitního systému selat: Redistribuce podskupin T lymfocytů

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F07%3A%230000222" target="_blank" >RIV/00027162:_____/07:#0000222 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Early postnatal development of the immune system of piglets: The redistribution of T lymphocyte subsets

Popis výsledku v původním jazyce

We have characterised postnatal changes in T lymphocyte subsets, especially gamma delta (gd) T lymphocytes, in blood, spleen and lymph nodes. Detection was carried out using two-colour flow cytometry and three-colour immunohistochemistry. During ontogeny, there was a significant increase in the total percentage of gd T cells in the spleen and blood. In the lymph nodes, there were no age-dependent changes in the total percentage of gd T cells, but the percentage of the gd TCR+CD8+ subpopulation significantly increased. The tissue distribution of gd TCR+CD8+ and gd TCR+CD8- cells in the lymph nodes is random and not collocated with a particular area of the organ. Furthermore, postnatal development was characterised by an increasing frequency of CD8+CD3+CD4-gdTCR-, which was compensated by a decreasing proportion of CD4+ lymphocytes. Double positive CD4+CD8+ lymphocytes were rare during the first month of life and a significant age-dependent increase of these cells was found in all the co

Název v anglickém jazyce

Early postnatal development of the immune system of piglets: The redistribution of T lymphocyte subsets

Popis výsledku anglicky

We have characterised postnatal changes in T lymphocyte subsets, especially gamma delta (gd) T lymphocytes, in blood, spleen and lymph nodes. Detection was carried out using two-colour flow cytometry and three-colour immunohistochemistry. During ontogeny, there was a significant increase in the total percentage of gd T cells in the spleen and blood. In the lymph nodes, there were no age-dependent changes in the total percentage of gd T cells, but the percentage of the gd TCR+CD8+ subpopulation significantly increased. The tissue distribution of gd TCR+CD8+ and gd TCR+CD8- cells in the lymph nodes is random and not collocated with a particular area of the organ. Furthermore, postnatal development was characterised by an increasing frequency of CD8+CD3+CD4-gdTCR-, which was compensated by a decreasing proportion of CD4+ lymphocytes. Double positive CD4+CD8+ lymphocytes were rare during the first month of life and a significant age-dependent increase of these cells was found in all the co

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

GJ - Choroby a škůdci zvířat, veterinární medicina

OECD FORD obor

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Projekt

<a href="/cs/project/1B44024" target="_blank" >1B44024: Metody zvýšení účinnosti vakcinačních postupů u hospodářských zvířat</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2007

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Cellular Immunology

ISSN

0008-8749

e-ISSN

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Svazek periodika

249

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

7

Strana od-do

73-79

Kód UT WoS článku

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EID výsledku v databázi Scopus

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