Antimicrobial and anticancer peptides

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F09%3A%230000542" target="_blank" >RIV/00027162:_____/09:#0000542 - isvavai.cz</a>

Výsledek na webu

—

DOI - Digital Object Identifier

—

Jazyk výsledku

angličtina

Název v původním jazyce

Antimicrobial and anticancer peptides

Popis výsledku v původním jazyce

Antimicrobial peptides are gene-coded polypeptides that exist in various species, ranging from bacteria, fungi, amphibians, plants, to animals, including humans. In invertebrates, they are the only host defense molecules, whereas in vertebrates these molecules are the key components of innate immunity and may serve as signal molecules to trigger further adaptive immune response. Their amino acid composition, amphipathicity, cationic charge and size allow them to attach to and insert into membrane bilayers to form pores by 'barrel-stave', 'carpet' or 'toroidal-pore' mechanisms. Cationic antimicrobial peptides provide new hope in a time when conventional antibiotics have been rapidly losing efficacy in the treatment of infections due to problems associated with resistance. It is extremely encouraging to observe these new compounds move through early preclinical to phase III clinical trials in such areas as infectious diseases, cancer and wound healing.

Název v anglickém jazyce

Antimicrobial and anticancer peptides

Popis výsledku anglicky

Antimicrobial peptides are gene-coded polypeptides that exist in various species, ranging from bacteria, fungi, amphibians, plants, to animals, including humans. In invertebrates, they are the only host defense molecules, whereas in vertebrates these molecules are the key components of innate immunity and may serve as signal molecules to trigger further adaptive immune response. Their amino acid composition, amphipathicity, cationic charge and size allow them to attach to and insert into membrane bilayers to form pores by 'barrel-stave', 'carpet' or 'toroidal-pore' mechanisms. Cationic antimicrobial peptides provide new hope in a time when conventional antibiotics have been rapidly losing efficacy in the treatment of infections due to problems associated with resistance. It is extremely encouraging to observe these new compounds move through early preclinical to phase III clinical trials in such areas as infectious diseases, cancer and wound healing.

Druh

D - Stať ve sborníku

CEP obor

EE - Mikrobiologie, virologie

OECD FORD obor

—

Projekt

—

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2009

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Collection

ISBN

978-80-86241-31-9

ISSN

—

e-ISSN

—

Počet stran výsledku

8

Strana od-do

—

Název nakladatele

Institute of Organic Chemistry and Biochemistry

Místo vydání

Praha

Místo konání akce

Praha

Datum konání akce

1. 1. 2009

Typ akce podle státní příslušnosti

EUR - Evropská akce

Kód UT WoS článku

—