Porcine mononuclear phagocyte subpopulations in the lung, blood and bone marrow: dynamics during inflammation induced by Actinobacillus pleuropneumoniae
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F10%3A%230000640" target="_blank" >RIV/00027162:_____/10:#0000640 - isvavai.cz</a>
Výsledek na webu
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DOI - Digital Object Identifier
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Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Porcine mononuclear phagocyte subpopulations in the lung, blood and bone marrow: dynamics during inflammation induced by Actinobacillus pleuropneumoniae
Popis výsledku v původním jazyce
The present study was aimed at describing porcine mononuclear phagocyte subpopulations infiltrating inflamed tissue of pigs under in vivo conditions. Actinobacillus pleuropneumoniae infection was used to induce an inflammatory response. CD172a, CD14, CD163, MHCII and CD203a cell surface molecules were used to identify mononuclear phagocyte by flow cytometry. Changes in mononuclear phagocyte subpopulations in the peripheral blood and bone marrow compartments along with the analysis of mononuclear phagocyte appearing in the inflamed lungs were assessed to elucidate the possible origin and maturation stages of the infiltrating mononuclear phagocyte. The mononuclear phagocyte population migrating to the inflamed lungs was positive for molecules CD14 and CD163 and positive or negative for molecules CD203a and MHCII. Based on results, two different maturation pathways of mononuclear phagocyte were suggested in pigs. The use of these pathways differs under inflammatory and non-inflammatory co
Název v anglickém jazyce
Porcine mononuclear phagocyte subpopulations in the lung, blood and bone marrow: dynamics during inflammation induced by Actinobacillus pleuropneumoniae
Popis výsledku anglicky
The present study was aimed at describing porcine mononuclear phagocyte subpopulations infiltrating inflamed tissue of pigs under in vivo conditions. Actinobacillus pleuropneumoniae infection was used to induce an inflammatory response. CD172a, CD14, CD163, MHCII and CD203a cell surface molecules were used to identify mononuclear phagocyte by flow cytometry. Changes in mononuclear phagocyte subpopulations in the peripheral blood and bone marrow compartments along with the analysis of mononuclear phagocyte appearing in the inflamed lungs were assessed to elucidate the possible origin and maturation stages of the infiltrating mononuclear phagocyte. The mononuclear phagocyte population migrating to the inflamed lungs was positive for molecules CD14 and CD163 and positive or negative for molecules CD203a and MHCII. Based on results, two different maturation pathways of mononuclear phagocyte were suggested in pigs. The use of these pathways differs under inflammatory and non-inflammatory co
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
GJ - Choroby a škůdci zvířat, veterinární medicina
OECD FORD obor
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Návaznosti výsledku
Projekt
Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)
Ostatní
Rok uplatnění
2010
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Veterinary Research
ISSN
0928-4249
e-ISSN
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Svazek periodika
41
Číslo periodika v rámci svazku
5
Stát vydavatele periodika
FR - Francouzská republika
Počet stran výsledku
14
Strana od-do
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Kód UT WoS článku
000284063300009
EID výsledku v databázi Scopus
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