Distribution of porcine monocytes in different lymphoid tissues and the lungs during experimental Actinobacillus pleuropneumoniae infection and the role of chemokines

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F13%3A%230001014" target="_blank" >RIV/00027162:_____/13:#0001014 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.veterinaryresearch.org/content/44/1/98" target="_blank" >http://www.veterinaryresearch.org/content/44/1/98</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/1297-9716-44-98" target="_blank" >10.1186/1297-9716-44-98</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Distribution of porcine monocytes in different lymphoid tissues and the lungs during experimental Actinobacillus pleuropneumoniae infection and the role of chemokines

Popis výsledku v původním jazyce

Monocytes play an essential role in the defense against bacterial pathogens. Bone marrow ( BM) and peripheral blood ( PB) monocytes in pigs consist of the main "steady-state" subpopulations: CD14(hi)/CD163(-)/SLA-DR- and CD14(low)/CD163(+)/SLA-DR+. During inflammation, the subpopulation of "inflammatory" monocytes expressing very high levels of CD163, but lacking the SLA-DR molecule (being CD14(low)/CD163(+)/SLA-DR-) appears in the BM and PB and replaces the CD14(low)/CD163(+)/SLA-DR+ subpopulation. However, current knowledge of monocyte migration into inflamed tissues in pigs is limited. The aim of the present study was to evaluate the distribution of "inflammatory" CD14(low)/CD163(+)/SLA-DR- monocytes during experimental inflammation induced by Actinobacillus pleuropneumoniae (APP) and a possible role for chemokines in attracting "inflammatory" CD14(low)/CD163(+)/SLA-DR- monocytes into the tissues. Monocyte subpopulations were detected by flow cytometry. Chemokines and chemokine rece

Název v anglickém jazyce

Distribution of porcine monocytes in different lymphoid tissues and the lungs during experimental Actinobacillus pleuropneumoniae infection and the role of chemokines

Popis výsledku anglicky

Monocytes play an essential role in the defense against bacterial pathogens. Bone marrow ( BM) and peripheral blood ( PB) monocytes in pigs consist of the main "steady-state" subpopulations: CD14(hi)/CD163(-)/SLA-DR- and CD14(low)/CD163(+)/SLA-DR+. During inflammation, the subpopulation of "inflammatory" monocytes expressing very high levels of CD163, but lacking the SLA-DR molecule (being CD14(low)/CD163(+)/SLA-DR-) appears in the BM and PB and replaces the CD14(low)/CD163(+)/SLA-DR+ subpopulation. However, current knowledge of monocyte migration into inflamed tissues in pigs is limited. The aim of the present study was to evaluate the distribution of "inflammatory" CD14(low)/CD163(+)/SLA-DR- monocytes during experimental inflammation induced by Actinobacillus pleuropneumoniae (APP) and a possible role for chemokines in attracting "inflammatory" CD14(low)/CD163(+)/SLA-DR- monocytes into the tissues. Monocyte subpopulations were detected by flow cytometry. Chemokines and chemokine rece

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EC - Imunologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Veterinary Research

ISSN

1297-9716

e-ISSN

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Svazek periodika

44

Číslo periodika v rámci svazku

98

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

16

Strana od-do

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Kód UT WoS článku

000326186800001

EID výsledku v databázi Scopus

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