Ingraft chimerism in lung transplantation - a study in a porcine model of obliterative bronchiolitis

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F11%3A%230000762" target="_blank" >RIV/00027162:_____/11:#0000762 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Ingraft chimerism in lung transplantation - a study in a porcine model of obliterative bronchiolitis

Popis výsledku v původním jazyce

We studied the influence of chimerism on bronchial epithelium and obliterative bronchiolitis (OB) development in pigs. Immunosuppressed and unimmunosuppressed bronchial allografts were serially obtained after transplantation. Histology was assessed and the fluorescence in situ hybridization method for Y chromosomes using pig-specific DNA-label was used to detect recipient derived cells in graft epithelium and bronchial wall, and donor cell migration to recipient organs. Early appearance of recipient-derived cells in the airway epithelium appeared predictive of epithelial destruction and of obliteration of the bronchial lumen All allografts with preserved epithelium showed epithelial chimerism throughout the follow-up. Antirejection medication did not prevent, but delayed the appearance of Y chromosome positive cells in the epithelium, or bronchial wall.

Název v anglickém jazyce

Ingraft chimerism in lung transplantation - a study in a porcine model of obliterative bronchiolitis

Popis výsledku anglicky

We studied the influence of chimerism on bronchial epithelium and obliterative bronchiolitis (OB) development in pigs. Immunosuppressed and unimmunosuppressed bronchial allografts were serially obtained after transplantation. Histology was assessed and the fluorescence in situ hybridization method for Y chromosomes using pig-specific DNA-label was used to detect recipient derived cells in graft epithelium and bronchial wall, and donor cell migration to recipient organs. Early appearance of recipient-derived cells in the airway epithelium appeared predictive of epithelial destruction and of obliteration of the bronchial lumen All allografts with preserved epithelium showed epithelial chimerism throughout the follow-up. Antirejection medication did not prevent, but delayed the appearance of Y chromosome positive cells in the epithelium, or bronchial wall.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FJ - Chirurgie včetně transplantologie

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Respiratory Research

ISSN

1465-9921

e-ISSN

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Svazek periodika

12

Číslo periodika v rámci svazku

56

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

7

Strana od-do

1-7

Kód UT WoS článku

000291448500001

EID výsledku v databázi Scopus

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