Polar Compounds Dominate in Vitro Effects of Sediment Extracts

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F11%3A%230000784" target="_blank" >RIV/00027162:_____/11:#0000784 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Polar Compounds Dominate in Vitro Effects of Sediment Extracts

Popis výsledku v původním jazyce

Sediment extracts from three polluted sites of the river Elbe basin,were fractionated using a novel online fractionation procedure. Resulting fractions were screened for mutagenic, aryl hydrocarbon receptor (AhR)-mediated, transthyretin (TTR)-binding, and estrogenic. activities and their potency to inhibit gap junctional intercellular communication (GJIC) to compare toxicity patterns and identify priority fractions. Additionally, more than 200 compounds and compound classes were identified using GC-MS/MS, LC-MS/MS, and HPL,C-DAD methods. For all investigated end, points, major activities were found in polar fractions, which are defined here as fractions containing dominantly compounds with atleast one polar functional group. Nonpolar PAR fractions contributed to mutagenic,andAhR-mediated activities while inhibitior of GJIC and estrogenic and TTR-binding activities were exclusively observed in the polar fractions. Known mutagens in polar fractions included nitro and dinitro-PAHs, azaare

Název v anglickém jazyce

Polar Compounds Dominate in Vitro Effects of Sediment Extracts

Popis výsledku anglicky

Sediment extracts from three polluted sites of the river Elbe basin,were fractionated using a novel online fractionation procedure. Resulting fractions were screened for mutagenic, aryl hydrocarbon receptor (AhR)-mediated, transthyretin (TTR)-binding, and estrogenic. activities and their potency to inhibit gap junctional intercellular communication (GJIC) to compare toxicity patterns and identify priority fractions. Additionally, more than 200 compounds and compound classes were identified using GC-MS/MS, LC-MS/MS, and HPL,C-DAD methods. For all investigated end, points, major activities were found in polar fractions, which are defined here as fractions containing dominantly compounds with atleast one polar functional group. Nonpolar PAR fractions contributed to mutagenic,andAhR-mediated activities while inhibitior of GJIC and estrogenic and TTR-binding activities were exclusively observed in the polar fractions. Known mutagens in polar fractions included nitro and dinitro-PAHs, azaare

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

DN - Vliv životního prostředí na zdraví

OECD FORD obor

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Projekt

<a href="/cs/project/GA525%2F08%2F1590" target="_blank" >GA525/08/1590: Identifikace endokrinních disruptorů, genotoxinů a nádorových promotorů v abiotických složkách městského a zemědělského prostředí</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Environmental Science & Technology

ISSN

0013-936X

e-ISSN

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Svazek periodika

45

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

6

Strana od-do

2384-2390

Kód UT WoS článku

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EID výsledku v databázi Scopus

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