DNA Vaccines for the Induction of Immune Responses in Mucosal Tisssues
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F15%3A%230001236" target="_blank" >RIV/00027162:_____/15:#0001236 - isvavai.cz</a>
Výsledek na webu
<a href="http://dx.doi.org/10.1016/B978-0-12-415847-4.15002-5" target="_blank" >http://dx.doi.org/10.1016/B978-0-12-415847-4.15002-5</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/B978-0-12-415847-4.15002-5" target="_blank" >10.1016/B978-0-12-415847-4.15002-5</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
DNA Vaccines for the Induction of Immune Responses in Mucosal Tisssues
Popis výsledku v původním jazyce
DNA vaccines represent an innovative approach allowing the induction of humoral and cell-mediated antigen-specific immune response in systemic and mucosal compartments. Vaccines consist of plasmid DNA-encoding antigens that become expressed in host cells, including species-specific posttranslational modifications. DNA vaccines elicit CD8 T cell responses in most experiments through cross-presentation of antigen. Because most pathogens invade hosts through mucosal surfaces, the induction of mucosal and systemic immunity is of paramount importance. Although systemic DNA vaccination exhibits high efficiency, generally weaker immune responses are induced by mucosal DNA administration. However, systemic immunization with selected viral and bacterial vaccines may also protect against mucosal infections. Furthermore, in contrast to high immunogenicity confirmed in small experimental animals, human DNA vaccines require further optimization to exhibit a protective effect. Therefore, various sys
Název v anglickém jazyce
DNA Vaccines for the Induction of Immune Responses in Mucosal Tisssues
Popis výsledku anglicky
DNA vaccines represent an innovative approach allowing the induction of humoral and cell-mediated antigen-specific immune response in systemic and mucosal compartments. Vaccines consist of plasmid DNA-encoding antigens that become expressed in host cells, including species-specific posttranslational modifications. DNA vaccines elicit CD8 T cell responses in most experiments through cross-presentation of antigen. Because most pathogens invade hosts through mucosal surfaces, the induction of mucosal and systemic immunity is of paramount importance. Although systemic DNA vaccination exhibits high efficiency, generally weaker immune responses are induced by mucosal DNA administration. However, systemic immunization with selected viral and bacterial vaccines may also protect against mucosal infections. Furthermore, in contrast to high immunogenicity confirmed in small experimental animals, human DNA vaccines require further optimization to exhibit a protective effect. Therefore, various sys
Klasifikace
Druh
C - Kapitola v odborné knize
CEP obor
EC - Imunologie
OECD FORD obor
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Návaznosti výsledku
Projekt
Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Ostatní
Rok uplatnění
2015
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název knihy nebo sborníku
Mucosal Immunology
ISBN
9780124158474
Počet stran výsledku
22
Strana od-do
1307-1328
Počet stran knihy
2564
Název nakladatele
Elsevier
Místo vydání
Nizozemí
Kód UT WoS kapitoly
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