DNA Vaccines for the Induction of Immune Responses in Mucosal Tissues

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F15%3A33157359" target="_blank" >RIV/61989592:15110/15:33157359 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1016/B978-0-12-415847-4.00067-7" target="_blank" >http://dx.doi.org/10.1016/B978-0-12-415847-4.00067-7</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/B978-0-12-415847-4.00067-7" target="_blank" >10.1016/B978-0-12-415847-4.00067-7</a>

Jazyk výsledku

angličtina

Název v původním jazyce

DNA Vaccines for the Induction of Immune Responses in Mucosal Tissues

Popis výsledku v původním jazyce

DNA vaccines represent an innovative approach allowing the induction of humoral and cell-mediated antigen-specific immune response in systemic and mucosal compartments. Vaccines consist of plasmid DNA-encoding antigens that become expressed in host cells, including species-specific posttranslational modifications. DNA vaccines elicit CD8 T cell responses in most experiments through cross-presentation of antigen. Because most pathogens invade hosts through mucosal surfaces, the induction of mucosal and systemic immunity is of paramount importance. Although systemic DNA vaccination exhibits high efficiency, generally weaker immune responses are induced by mucosal DNA administration. However, systemic immunization with selected viral and bacterial vaccines may also protect against mucosal infections. Furthermore, in contrast to high immunogenicity confirmed in small experimental animals, human DNA vaccines require further optimization to exhibit a protective effect. Therefore, various sys

Název v anglickém jazyce

DNA Vaccines for the Induction of Immune Responses in Mucosal Tissues

Popis výsledku anglicky

DNA vaccines represent an innovative approach allowing the induction of humoral and cell-mediated antigen-specific immune response in systemic and mucosal compartments. Vaccines consist of plasmid DNA-encoding antigens that become expressed in host cells, including species-specific posttranslational modifications. DNA vaccines elicit CD8 T cell responses in most experiments through cross-presentation of antigen. Because most pathogens invade hosts through mucosal surfaces, the induction of mucosal and systemic immunity is of paramount importance. Although systemic DNA vaccination exhibits high efficiency, generally weaker immune responses are induced by mucosal DNA administration. However, systemic immunization with selected viral and bacterial vaccines may also protect against mucosal infections. Furthermore, in contrast to high immunogenicity confirmed in small experimental animals, human DNA vaccines require further optimization to exhibit a protective effect. Therefore, various sys

Druh

C - Kapitola v odborné knize

CEP obor

EC - Imunologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Mucosal Immunology

ISBN

978-0-12-415847-4

Počet stran výsledku

29

Strana od-do

"1307-1335"

Počet stran knihy

2564

Název nakladatele

Elsevier

Místo vydání

Amsterdam

Kód UT WoS kapitoly

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