A deep phylogeny of viral and cellular right-hand polymerases

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F15%3A%230001319" target="_blank" >RIV/00027162:_____/15:#0001319 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.journals.elsevier.com/infection-genetics-and-evolution" target="_blank" >http://www.journals.elsevier.com/infection-genetics-and-evolution</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.meegid.2015.09.026" target="_blank" >10.1016/j.meegid.2015.09.026</a>

Jazyk výsledku

angličtina

Název v původním jazyce

A deep phylogeny of viral and cellular right-hand polymerases

Popis výsledku v původním jazyce

Right-hand polymerases are important players in genome replication and repair in cellular organisms as well as in viruses. Although the evolutionary relationships of right-hand polymerases within each family have been proposed, evolutionary relationshipsbetween families remain elusive because their sequence similarity is too low to allow classical phylogenetic analyses. The structure of viral RNA-dependent RNA polymerases recently was shown to be useful in inferring their evolution. Here, we address evolutionary relationships between right-hand polymerase families by combining sequence and structure information. We used a set of 22 viral and cellular polymerases representing all right-hand polymerase families with known protein structure. In contrastto previous studies, which focused only on the evolution of particular families, the current approach allowed us to present the first robust phylogenetic analysis unifying evolution of all right-hand polymerase families. All polymerase fa

Název v anglickém jazyce

A deep phylogeny of viral and cellular right-hand polymerases

Popis výsledku anglicky

Right-hand polymerases are important players in genome replication and repair in cellular organisms as well as in viruses. Although the evolutionary relationships of right-hand polymerases within each family have been proposed, evolutionary relationshipsbetween families remain elusive because their sequence similarity is too low to allow classical phylogenetic analyses. The structure of viral RNA-dependent RNA polymerases recently was shown to be useful in inferring their evolution. Here, we address evolutionary relationships between right-hand polymerase families by combining sequence and structure information. We used a set of 22 viral and cellular polymerases representing all right-hand polymerase families with known protein structure. In contrastto previous studies, which focused only on the evolution of particular families, the current approach allowed us to present the first robust phylogenetic analysis unifying evolution of all right-hand polymerase families. All polymerase fa

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EE - Mikrobiologie, virologie

OECD FORD obor

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Projekt

<a href="/cs/project/LO1218" target="_blank" >LO1218: Zdravé zvíře jako zdroj zdravé potraviny</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

INFECTION GENETICS AND EVOLUTION

ISSN

0300-8126

e-ISSN

—

Svazek periodika

36

Číslo periodika v rámci svazku

Dec

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

12

Strana od-do

275-286

Kód UT WoS článku

000310114600016

EID výsledku v databázi Scopus

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