Translation in the mammalian oocyte in space and time

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F16%3AN0000129" target="_blank" >RIV/00027162:_____/16:N0000129 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/67985904:_____/16:00459927

Výsledek na webu

<a href="http://link.springer.com/article/10.1007/s00441-015-2269-6" target="_blank" >http://link.springer.com/article/10.1007/s00441-015-2269-6</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00441-015-2269-6" target="_blank" >10.1007/s00441-015-2269-6</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Translation in the mammalian oocyte in space and time

Popis výsledku v původním jazyce

A hallmark of oocyte development in mammals is the dependence on the translation and utilization of stored RNA and proteins rather than the de novo transcription of genes in order to sustain meiotic progression and early embryo development. In the absence of transcription, the completion of meiosis and early embryo development in mammals relies significantly on maternally synthesized RNAs. Posttranscriptional control of gene expression at the translational level has emerged as an important cellular function in normal development. Therefore, the regulation of gene expression in oocytes is controlled almost exclusively at the level of mRNA and protein stabilization and protein synthesis. This current review is focused on the recently emerged findings on RNA distribution related to the temporal and spatial translational control of the meiotic progression of the mammalian oocyte.

Název v anglickém jazyce

Translation in the mammalian oocyte in space and time

Popis výsledku anglicky

A hallmark of oocyte development in mammals is the dependence on the translation and utilization of stored RNA and proteins rather than the de novo transcription of genes in order to sustain meiotic progression and early embryo development. In the absence of transcription, the completion of meiosis and early embryo development in mammals relies significantly on maternally synthesized RNAs. Posttranscriptional control of gene expression at the translational level has emerged as an important cellular function in normal development. Therefore, the regulation of gene expression in oocytes is controlled almost exclusively at the level of mRNA and protein stabilization and protein synthesis. This current review is focused on the recently emerged findings on RNA distribution related to the temporal and spatial translational control of the meiotic progression of the mammalian oocyte.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

CELL AND TISSUE RESEARCH

ISSN

0302-766X

e-ISSN

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Svazek periodika

363

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

16

Strana od-do

69-84

Kód UT WoS článku

000369322500007

EID výsledku v databázi Scopus

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