Translational regulation in the mammalian oocyte

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F17%3A00483024" target="_blank" >RIV/67985904:_____/17:00483024 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1007/978-3-319-60855-6_12" target="_blank" >http://dx.doi.org/10.1007/978-3-319-60855-6_12</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/978-3-319-60855-6_12" target="_blank" >10.1007/978-3-319-60855-6_12</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Translational regulation in the mammalian oocyte

Popis výsledku v původním jazyce

Fully grown oocytes arrest meiosis at prophase I and deposit maternal RNAs. A subset of maternal transcripts is stored in a dormant state in the oocyte, and the timely driven translation of specific mRNAs guides meiotic progression, the oocyte-embryo transition, and early embryo development. In the absence of transcription, the regulation of gene expression in oocytes is controlled almost exclusively at the level of transcriptome and proteome stabilization and at the level of protein synthesis. This chapter focuses on the recent findings on RNA distribution related to the temporal and spatial translational control of the meiotic cycle progression in mammalian oocytes. We discuss the most relevant mechanisms involved in the organization of the oocyte’s maternal transcriptome storage and localization, and the regulation of translation, in correlation with the regulation of oocyte meiotic progression.

Název v anglickém jazyce

Translational regulation in the mammalian oocyte

Popis výsledku anglicky

Fully grown oocytes arrest meiosis at prophase I and deposit maternal RNAs. A subset of maternal transcripts is stored in a dormant state in the oocyte, and the timely driven translation of specific mRNAs guides meiotic progression, the oocyte-embryo transition, and early embryo development. In the absence of transcription, the regulation of gene expression in oocytes is controlled almost exclusively at the level of transcriptome and proteome stabilization and at the level of protein synthesis. This chapter focuses on the recent findings on RNA distribution related to the temporal and spatial translational control of the meiotic cycle progression in mammalian oocytes. We discuss the most relevant mechanisms involved in the organization of the oocyte’s maternal transcriptome storage and localization, and the regulation of translation, in correlation with the regulation of oocyte meiotic progression.

Druh

C - Kapitola v odborné knize

CEP obor

—

OECD FORD obor

10608 - Biochemistry and molecular biology

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Oocytes

ISBN

978-3-319-60855-6

Počet stran výsledku

39

Strana od-do

257-295

Počet stran knihy

260

Název nakladatele

Springer International Publishing

Místo vydání

Wien

Kód UT WoS kapitoly

000440267800013