Effect of dietary fish oil on selected markers of an inflammatory status in pigs

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F16%3AN0000146" target="_blank" >RIV/00027162:_____/16:N0000146 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/62156489:43210/16:43910213

Výsledek na webu

<a href="https://mnet.mendelu.cz/mendelnet2016/mnet_2016_full.pdf" target="_blank" >https://mnet.mendelu.cz/mendelnet2016/mnet_2016_full.pdf</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Effect of dietary fish oil on selected markers of an inflammatory status in pigs

Popis výsledku v původním jazyce

The objective of the experiment was to test a hypothesis that the biologically active substances present in fish oil (eicosapentaenoic acid, EPA, and docosahexaenoic acid, DHA) are able to stabilize inflammatory status in an organism. Thirty two pigs (Large White x Landrace) at the age of eight weeks with the mean live weight of 25.5 kg were used as a model organism. The pigs were divided into two groups with 16 animals each; the experimental and control group was fed the basic feed mixture with 2.5% of fish oil (F) and 2.5% of palm oil (P), respectively. The F - and P - pigs were randomly divided into two groups 70th day of fattening, and eight F - and eight P - pigs were treated with E. coli lipopolysaccharide (LPS). After anesthetizing, pigs were sacrificed by bleeding, the blood and liver samples were taken, and expression of the liver genes coding for 7 selected cytokines and plasma concentration of adiponectin and three cytokines was determined. No significant effect (P > 0.05) of dietary intervention on feed intake, live weight and live weight gain was found. Fish oil tended to increase (P > 0.05) relative expression of all tested cytokine genes, the effect being significant (P < 0.05) in the case of IL - 6 and TGF - beta 1 after LPS application. Fish oil also increased (P < 0.05) plasma concentration of TNF alpha in pigs treated with LPS. On the other hand, fish oil tended to decrease (P = 0.22) plasma adiponectin in comparison with palm oil. The present study did not confirm anti-inflammatory effect of fish oil.

Název v anglickém jazyce

Effect of dietary fish oil on selected markers of an inflammatory status in pigs

Popis výsledku anglicky

The objective of the experiment was to test a hypothesis that the biologically active substances present in fish oil (eicosapentaenoic acid, EPA, and docosahexaenoic acid, DHA) are able to stabilize inflammatory status in an organism. Thirty two pigs (Large White x Landrace) at the age of eight weeks with the mean live weight of 25.5 kg were used as a model organism. The pigs were divided into two groups with 16 animals each; the experimental and control group was fed the basic feed mixture with 2.5% of fish oil (F) and 2.5% of palm oil (P), respectively. The F - and P - pigs were randomly divided into two groups 70th day of fattening, and eight F - and eight P - pigs were treated with E. coli lipopolysaccharide (LPS). After anesthetizing, pigs were sacrificed by bleeding, the blood and liver samples were taken, and expression of the liver genes coding for 7 selected cytokines and plasma concentration of adiponectin and three cytokines was determined. No significant effect (P > 0.05) of dietary intervention on feed intake, live weight and live weight gain was found. Fish oil tended to increase (P > 0.05) relative expression of all tested cytokine genes, the effect being significant (P < 0.05) in the case of IL - 6 and TGF - beta 1 after LPS application. Fish oil also increased (P < 0.05) plasma concentration of TNF alpha in pigs treated with LPS. On the other hand, fish oil tended to decrease (P = 0.22) plasma adiponectin in comparison with palm oil. The present study did not confirm anti-inflammatory effect of fish oil.

Druh

D - Stať ve sborníku

CEP obor

GJ - Choroby a škůdci zvířat, veterinární medicina

OECD FORD obor

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Projekt

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Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

MendelNet 2016

ISBN

978-80-7509-443-8

ISSN

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e-ISSN

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Počet stran výsledku

5

Strana od-do

819-823

Název nakladatele

Mendelova Univerzita v Brně

Místo vydání

Brno

Místo konání akce

Brno

Datum konání akce

9. 11. 2016

Typ akce podle státní příslušnosti

EUR - Evropská akce

Kód UT WoS článku

000392968500147