Immune response to sublingualy delievered recombinant antigenes in experimental mice

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F18%3AN0000087" target="_blank" >RIV/00027162:_____/18:N0000087 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Immune response to sublingualy delievered recombinant antigenes in experimental mice

Popis výsledku v původním jazyce

The oromucosal route of administration is a route for vaccine delivery alternative to parenteral invasive routes such as intramuscular, subcutaneous or intradermal ones. It offers posibility to induce both mucosal and systemic responses without potential to induce mucosal tolerance. Sublingual vaccination does not require strictly sterile vaccine application conditions, and, in contrast to other mucosally effective intranasal route, it does not elicit rare but severe toxic side effects caused by penetration of antigen and adjuvants across olfactory epithelium, leading to damage to olfactory nerves or Bell´s palsy. Using experimental mice model, several recombinant proteins and inactive virus vaccine were tested for elicitation of mucosal and systemic responses after sublingual dropwise, sublingual patch, and parenteral administrations. Sublingual patches immunization induces both mucosal and systemic responses of various intensities dependent on antigen nature and adjuvant usage. No side effects were observed in any experimental animals.

Název v anglickém jazyce

Immune response to sublingualy delievered recombinant antigenes in experimental mice

Popis výsledku anglicky

The oromucosal route of administration is a route for vaccine delivery alternative to parenteral invasive routes such as intramuscular, subcutaneous or intradermal ones. It offers posibility to induce both mucosal and systemic responses without potential to induce mucosal tolerance. Sublingual vaccination does not require strictly sterile vaccine application conditions, and, in contrast to other mucosally effective intranasal route, it does not elicit rare but severe toxic side effects caused by penetration of antigen and adjuvants across olfactory epithelium, leading to damage to olfactory nerves or Bell´s palsy. Using experimental mice model, several recombinant proteins and inactive virus vaccine were tested for elicitation of mucosal and systemic responses after sublingual dropwise, sublingual patch, and parenteral administrations. Sublingual patches immunization induces both mucosal and systemic responses of various intensities dependent on antigen nature and adjuvant usage. No side effects were observed in any experimental animals.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

30102 - Immunology

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů