Polycyclic aromatic hydrocarbons and disruption of steroid signaling

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F18%3AN0000268" target="_blank" >RIV/00027162:_____/18:N0000268 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68081707:_____/18:00522202

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S2468202018300500" target="_blank" >https://www.sciencedirect.com/science/article/pii/S2468202018300500</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.cotox.2018.12.003" target="_blank" >10.1016/j.cotox.2018.12.003</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Polycyclic aromatic hydrocarbons and disruption of steroid signaling

Popis výsledku v původním jazyce

Polycyclic aromatic hydrocarbons (PAHs) are widely distributed environmental pollutants that have been primarily studied as mutagenic and genotoxic compounds. Nevertheless, a number of studies have also indicated that PAHs may, either directly or indirectly, interfere with steroid receptors, in particular, with estrogen signaling. The outcome of interactions of PAHs with steroid receptors may be of relevance both to carcinogenic and endocrine disrupting activities of PAHs. This review discusses current insights into the mechanisms underlying the diversity of effects of PAHs (or their mixtures) on steroid signaling, focusing on the role of crosstalk between estrogen receptors and the aryl hydrocarbon receptor, direct effects of PAHs on estrogen signaling, and on the contribution of metabolism to estrogen-like effects of some PAHs. Finally, we comment the available data on interactions of PAHs with other nuclear receptors that are relevant for signaling of androgen receptor, glucocorticoid receptor, and others.

Název v anglickém jazyce

Polycyclic aromatic hydrocarbons and disruption of steroid signaling

Popis výsledku anglicky

Polycyclic aromatic hydrocarbons (PAHs) are widely distributed environmental pollutants that have been primarily studied as mutagenic and genotoxic compounds. Nevertheless, a number of studies have also indicated that PAHs may, either directly or indirectly, interfere with steroid receptors, in particular, with estrogen signaling. The outcome of interactions of PAHs with steroid receptors may be of relevance both to carcinogenic and endocrine disrupting activities of PAHs. This review discusses current insights into the mechanisms underlying the diversity of effects of PAHs (or their mixtures) on steroid signaling, focusing on the role of crosstalk between estrogen receptors and the aryl hydrocarbon receptor, direct effects of PAHs on estrogen signaling, and on the contribution of metabolism to estrogen-like effects of some PAHs. Finally, we comment the available data on interactions of PAHs with other nuclear receptors that are relevant for signaling of androgen receptor, glucocorticoid receptor, and others.

Druh

J_SC - Článek v periodiku v databázi SCOPUS

CEP obor

—

OECD FORD obor

40301 - Veterinary science

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Current Opinion in Toxicology

ISSN

2468-2020

e-ISSN

—

Svazek periodika

11-12

Číslo periodika v rámci svazku

October - December 2018

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

8

Strana od-do

27-34

Kód UT WoS článku

—

EID výsledku v databázi Scopus

2-s2.0-85059803793