Nový model pro hodnocení endokrinní disrupce steroidogeneze v buněčné linii H295R

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F05%3A00014599" target="_blank" >RIV/00216224:14310/05:00014599 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

New model for evaluation of endocrine disruption of steroidogenesis in H295R cell line

Popis výsledku v původním jazyce

One of the most hazardous properties of xenobiotics is their ability to interact with endocrine system of the organisms leading to number of negative consequences. After discovery of endocrine disrupting potential of wide range of environmental pollutants, the main concern was devoted to study of mechanism of interaction between xenobiotic compounds and steroid hormone receptors (particularly interaction with estrogenic receptor). Less attention was focused on other parts of this signaling pathway, suchas steroidogenesis, which is involved in steroid signaling pathway that regulates many crucial physiologic processes such as carcinogenesis, immunotoxicity or reduced fecundity. We have developed a model for assessment of the potency of various chemicals or their mixtures (pharmaceuticals, environmental contaminants, pesticides...) to affect levels of produced steroids. The model is based on a human carcinoma cell line H295R, which retains the ability to synthesize most of the important

Název v anglickém jazyce

New model for evaluation of endocrine disruption of steroidogenesis in H295R cell line

Popis výsledku anglicky

One of the most hazardous properties of xenobiotics is their ability to interact with endocrine system of the organisms leading to number of negative consequences. After discovery of endocrine disrupting potential of wide range of environmental pollutants, the main concern was devoted to study of mechanism of interaction between xenobiotic compounds and steroid hormone receptors (particularly interaction with estrogenic receptor). Less attention was focused on other parts of this signaling pathway, suchas steroidogenesis, which is involved in steroid signaling pathway that regulates many crucial physiologic processes such as carcinogenesis, immunotoxicity or reduced fecundity. We have developed a model for assessment of the potency of various chemicals or their mixtures (pharmaceuticals, environmental contaminants, pesticides...) to affect levels of produced steroids. The model is based on a human carcinoma cell line H295R, which retains the ability to synthesize most of the important

Druh

D - Stať ve sborníku

CEP obor

DN - Vliv životního prostředí na zdraví

OECD FORD obor

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Projekt

<a href="/cs/project/GP525%2F05%2FP160" target="_blank" >GP525/05/P160: In vitro modely pro studium endokrinní disrupce - účinky tradičních a nových typů persistentních organických polutantů</a><br>

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2005

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

ECOTOX 2005

ISBN

8021037997

ISSN

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e-ISSN

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Počet stran výsledku

1

Strana od-do

29

Název nakladatele

Brno : Masaryk University, 2005.

Místo vydání

Brno

Místo konání akce

Brno

Datum konání akce

5. 9. 2005

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

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