Effects of antidepressants with different modes of action on early life stages of fish and amphibians

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F19%3AN0000171" target="_blank" >RIV/00027162:_____/19:N0000171 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/62157124:16270/19:43877479

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S0269749119304257?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0269749119304257?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.envpol.2019.112999" target="_blank" >10.1016/j.envpol.2019.112999</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Effects of antidepressants with different modes of action on early life stages of fish and amphibians

Popis výsledku v původním jazyce

Drugs are excreted from the human body as both original substances and as metabolites and enter aquatic environment through waste water. The aim of this study was to widen the current knowledge considering the effects of waterborne antidepressants with different modes of action of amitriptyline, venlafaxine, sertraline on embryos of non-target aquatic biota in fish (represented by Danio rerio) and amphibians (represented by Xenopus tropicalis). The tested concentrations were 0.3; 3; 30; 300 and 3000 mg/L in case of amitriptyline and venlafaxine and 0.1; 1; 10; 100 and 1000 mg/L for sertraline. Test on zebrafish embryos was carried out until 144 h post fertilization, while test on Xenopus embryos was terminated after 48 h. Lethal and sublethal effects as well as swimming alterations were observed at higher tested concentrations that are not present in the environment. In contrast, mRNA expression of genes related to heart, eye, brain and bone development (nkx2.5, otx 2, bmp4 and pax 6) seems to be impacted also at environmentally relevant concentrations. In a wider context, this study reveals several indications on the ability of antidepressants to affect non target animals occupying environments which may be contaminated by such compounds.

Název v anglickém jazyce

Effects of antidepressants with different modes of action on early life stages of fish and amphibians

Popis výsledku anglicky

Drugs are excreted from the human body as both original substances and as metabolites and enter aquatic environment through waste water. The aim of this study was to widen the current knowledge considering the effects of waterborne antidepressants with different modes of action of amitriptyline, venlafaxine, sertraline on embryos of non-target aquatic biota in fish (represented by Danio rerio) and amphibians (represented by Xenopus tropicalis). The tested concentrations were 0.3; 3; 30; 300 and 3000 mg/L in case of amitriptyline and venlafaxine and 0.1; 1; 10; 100 and 1000 mg/L for sertraline. Test on zebrafish embryos was carried out until 144 h post fertilization, while test on Xenopus embryos was terminated after 48 h. Lethal and sublethal effects as well as swimming alterations were observed at higher tested concentrations that are not present in the environment. In contrast, mRNA expression of genes related to heart, eye, brain and bone development (nkx2.5, otx 2, bmp4 and pax 6) seems to be impacted also at environmentally relevant concentrations. In a wider context, this study reveals several indications on the ability of antidepressants to affect non target animals occupying environments which may be contaminated by such compounds.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

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OECD FORD obor

40301 - Veterinary science

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Environmental Pollution

ISSN

0269-7491

e-ISSN

1873-6424

Svazek periodika

254

Číslo periodika v rámci svazku

NOV 2019

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

9

Strana od-do

112999

Kód UT WoS článku

000488887500027

EID výsledku v databázi Scopus

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