Comparison of exosomes isolation methods from human blood serum - poster

Kód výsledku v IS VaVaI

RIV/00027162:_____/19:N0000174 - isvavai.cz

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Comparison of exosomes isolation methods from human blood serum - poster

Popis výsledku v původním jazyce

Exosomes are extracellular vesicles EVs of 30 to 150 nm in diameter occurring in various types of fluids in the human body, such as serum, urine or cerebrospinal fluid Exosomes are excreted by most types of cells and play an important role in cell to cell communication Exosomal cargo including proteins, mRNAs, non coding RNAs and other bioactive molecules may vary depending on the character of originating cell. Exosomes derived from tumour cells transfer specific molecules that can modulate the activity of recipient cells and therefore contribute to tumour progression, metastasis, drug resistance or escape from immune system These extracellular vesicles appear to be promising non invasive biomarkers for early detection of cancer, monitoring disease progression or therapy response because of their specific content. Since obtaining a pure fraction of exosomes is essential for utilizing exosomes as biomarkers, it is crucial to determine an appropriate exosome isolation method.

Název v anglickém jazyce

Comparison of exosomes isolation methods from human blood serum - poster

Popis výsledku anglicky

Exosomes are extracellular vesicles EVs of 30 to 150 nm in diameter occurring in various types of fluids in the human body, such as serum, urine or cerebrospinal fluid Exosomes are excreted by most types of cells and play an important role in cell to cell communication Exosomal cargo including proteins, mRNAs, non coding RNAs and other bioactive molecules may vary depending on the character of originating cell. Exosomes derived from tumour cells transfer specific molecules that can modulate the activity of recipient cells and therefore contribute to tumour progression, metastasis, drug resistance or escape from immune system These extracellular vesicles appear to be promising non invasive biomarkers for early detection of cancer, monitoring disease progression or therapy response because of their specific content. Since obtaining a pure fraction of exosomes is essential for utilizing exosomes as biomarkers, it is crucial to determine an appropriate exosome isolation method.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

10609 - Biochemical research methods

Projekt

EF15_003/0000495: FIT (Farmakologie, Imunoterapie, nanoToxikologie)

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů