Influence of formulation and process parameters on the properties of cu2+/alginate particles prepared by external ionic gelation evaluated by principal component analysis

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F19%3AN0000217" target="_blank" >RIV/00027162:_____/19:N0000217 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.prolekare.cz/casopisy/ceska-slovenska-farmacie/2019-2-20/vliv-formulacnich-a-procesnich-parametru-na-vlastnosti-cu2-alginatovych-castic-pripravenych-vnejsi-iontovou-gelaci-hodnoceny-analyzou-hlavnich-komponent-miroslava-pavelkova-jakub-vyslouzil-katerina-kubova-sylvie-pavlokova-113129/download?hl=cs" target="_blank" >https://www.prolekare.cz/casopisy/ceska-slovenska-farmacie/2019-2-20/vliv-formulacnich-a-procesnich-parametru-na-vlastnosti-cu2-alginatovych-castic-pripravenych-vnejsi-iontovou-gelaci-hodnoceny-analyzou-hlavnich-komponent-miroslava-pavelkova-jakub-vyslouzil-katerina-kubova-sylvie-pavlokova-113129/download?hl=cs</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Influence of formulation and process parameters on the properties of cu2+/alginate particles prepared by external ionic gelation evaluated by principal component analysis

Popis výsledku v původním jazyce

Currently, the method of external ionic gelation for the preparation of alginate particles is successfully used not only in the field of pharmacy and medicine, but also especially in the field of biotechnology. Therefore, the preparation of alginate particles and their subsequent evaluation using principal component analysis was the key task of our experiment. To optimize this method, we focused on the evaluation of the effect of formulation (the polymer concentration, the hardening solution concentration) and process parameters (the outer diameter of the injection needle) on the properties of the resulting beads (yield, sphericity factor, equivalent diameter and swelling capacity at pH 6). Using multivariate data analysis, the major influence on the resulting properties of the prepared particles was confirmed only in sodium alginate concentration. Obtained results verified the reliable and safe potential of the external ionic gelation for preparation alginate-based particulate dosage forms.

Název v anglickém jazyce

Influence of formulation and process parameters on the properties of cu2+/alginate particles prepared by external ionic gelation evaluated by principal component analysis

Popis výsledku anglicky

Currently, the method of external ionic gelation for the preparation of alginate particles is successfully used not only in the field of pharmacy and medicine, but also especially in the field of biotechnology. Therefore, the preparation of alginate particles and their subsequent evaluation using principal component analysis was the key task of our experiment. To optimize this method, we focused on the evaluation of the effect of formulation (the polymer concentration, the hardening solution concentration) and process parameters (the outer diameter of the injection needle) on the properties of the resulting beads (yield, sphericity factor, equivalent diameter and swelling capacity at pH 6). Using multivariate data analysis, the major influence on the resulting properties of the prepared particles was confirmed only in sodium alginate concentration. Obtained results verified the reliable and safe potential of the external ionic gelation for preparation alginate-based particulate dosage forms.

Druh

J_SC - Článek v periodiku v databázi SCOPUS

CEP obor

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OECD FORD obor

30104 - Pharmacology and pharmacy

Projekt

<a href="/cs/project/EF15_003%2F0000495" target="_blank" >EF15_003/0000495: FIT (Farmakologie, Imunoterapie, nanoToxikologie)</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Česká a slovenská farmacie

ISSN

1210-7816

e-ISSN

1805-4439

Svazek periodika

68

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

9

Strana od-do

69-77

Kód UT WoS článku

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EID výsledku v databázi Scopus

2-s2.0-85070076595