Could 5′-N and S ProTide analogues work as prodrugs of antiviral agents?

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F20%3AN0000015" target="_blank" >RIV/00027162:_____/20:N0000015 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60077344:_____/20:00519335 RIV/61388963:_____/20:00519335

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S0960894X19308753?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0960894X19308753?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.bmcl.2019.126897" target="_blank" >10.1016/j.bmcl.2019.126897</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Could 5′-N and S ProTide analogues work as prodrugs of antiviral agents?

Popis výsledku v původním jazyce

The nucleoside/nucleotide derived antiviral agents have been the most important components of antiviral therapy used in clinics. Recently, the focus of the medicinal chemists within this exciting research field has been affected mainly by the lack of effective therapies for the Hepatitis C virus (HCV) infection and several other “neglected” diseases caused by viruses such as Zika or Dengue. 2′-Methyl modified nucleosides and their monophosphate prodrugs (ProTides) have revolutionized the therapies for HCV in the last few years and, according to the latest research efforts, have also brought a promise for treatment of diseases caused by other members of Flaviviridae family. Here, we report on the design and synthesis of 5’-N and S modified ProTides derived from 2′-methyladenosine. We studied potential applicability of these derivatives as prodrugs of this archetypal antiviral compound.

Název v anglickém jazyce

Could 5′-N and S ProTide analogues work as prodrugs of antiviral agents?

Popis výsledku anglicky

The nucleoside/nucleotide derived antiviral agents have been the most important components of antiviral therapy used in clinics. Recently, the focus of the medicinal chemists within this exciting research field has been affected mainly by the lack of effective therapies for the Hepatitis C virus (HCV) infection and several other “neglected” diseases caused by viruses such as Zika or Dengue. 2′-Methyl modified nucleosides and their monophosphate prodrugs (ProTides) have revolutionized the therapies for HCV in the last few years and, according to the latest research efforts, have also brought a promise for treatment of diseases caused by other members of Flaviviridae family. Here, we report on the design and synthesis of 5’-N and S modified ProTides derived from 2′-methyladenosine. We studied potential applicability of these derivatives as prodrugs of this archetypal antiviral compound.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10613 - Zoology

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

ISSN

0960-894X

e-ISSN

1464-3405

Svazek periodika

30

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

4

Strana od-do

126897

Kód UT WoS článku

000507987200013

EID výsledku v databázi Scopus

2-s2.0-85077142100