Carp Edema Virus Infection Is Associated With Severe Metabolic Disturbance in Fish

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F21%3AN0000066" target="_blank" >RIV/00027162:_____/21:N0000066 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/62157124:16270/21:43879275 RIV/62156489:43210/21:43919911

Výsledek na webu

<a href="https://www.frontiersin.org/articles/10.3389/fvets.2021.679970/full" target="_blank" >https://www.frontiersin.org/articles/10.3389/fvets.2021.679970/full</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3389/fvets.2021.679970" target="_blank" >10.3389/fvets.2021.679970</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Carp Edema Virus Infection Is Associated With Severe Metabolic Disturbance in Fish

Popis výsledku v původním jazyce

Emerging viral diseases associated with significant mortality challenge the economy of common carp aquaculture. It is therefore necessary to disentangle how infected fish cope with progressive disease pathology, losing their ability for homeostatic maintenance of key physiological parameters. Having an opportunity to examine diseased carps and those that stayed healthy in the same storage pond under conditions of natural carp edema virus (CEV) infection outbreak, here we contribute to better understanding of the CEV disease pathophysiology. The disease status of fish was determined using virus identification with polymerase chain reaction combined with gill pathology. Compared with control healthy carps, the blood chemistry profile analysis of CEV-diseased fish revealed major disruption in electrolyte and acid-base balance (i.e. hyponatremia, hypochloremia, hyperphosphatemia, elevated pH, base excess and anion gap, and decreased partial dissolved carbon dioxide), hyperproteinemia, hyperalbuminemia, hypotonic dehydration, endogenous hyperammonemia, decreased lactate and increased creatinine, alkaline phosphatase, alanine aminotransferase and aspartate aminotransferase. Red blood cell associated haematology variables were also elevated. The multivariate pattern of responses of blood chemistry variables (driven by sodium, pH, partial dissolved carbon dioxide, ammonia and albumin in the principal component analysis) discriminated clearly between CEV-diseased and control carps. To conclude, we show that CEV infection of carps exerts complex adverse effects and results in severe metabolic disturbance due to impaired respiratory and excretory functions of gills

Název v anglickém jazyce

Carp Edema Virus Infection Is Associated With Severe Metabolic Disturbance in Fish

Popis výsledku anglicky

Emerging viral diseases associated with significant mortality challenge the economy of common carp aquaculture. It is therefore necessary to disentangle how infected fish cope with progressive disease pathology, losing their ability for homeostatic maintenance of key physiological parameters. Having an opportunity to examine diseased carps and those that stayed healthy in the same storage pond under conditions of natural carp edema virus (CEV) infection outbreak, here we contribute to better understanding of the CEV disease pathophysiology. The disease status of fish was determined using virus identification with polymerase chain reaction combined with gill pathology. Compared with control healthy carps, the blood chemistry profile analysis of CEV-diseased fish revealed major disruption in electrolyte and acid-base balance (i.e. hyponatremia, hypochloremia, hyperphosphatemia, elevated pH, base excess and anion gap, and decreased partial dissolved carbon dioxide), hyperproteinemia, hyperalbuminemia, hypotonic dehydration, endogenous hyperammonemia, decreased lactate and increased creatinine, alkaline phosphatase, alanine aminotransferase and aspartate aminotransferase. Red blood cell associated haematology variables were also elevated. The multivariate pattern of responses of blood chemistry variables (driven by sodium, pH, partial dissolved carbon dioxide, ammonia and albumin in the principal component analysis) discriminated clearly between CEV-diseased and control carps. To conclude, we show that CEV infection of carps exerts complex adverse effects and results in severe metabolic disturbance due to impaired respiratory and excretory functions of gills

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

40103 - Fishery

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Frontiers in Veterinary Science

ISSN

2297-1769

e-ISSN

2297-1769

Svazek periodika

8

Číslo periodika v rámci svazku

19 May 2021

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

9

Strana od-do

—

Kód UT WoS článku

000656847800001

EID výsledku v databázi Scopus

2-s2.0-85107285679